Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.33 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SLC6A6 | P31641 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27984273 | 0.90 | TSHR (0.35) | TSHRTDP1PTGS1PDE4ATP53 | |
| Fluoromethane SCHEMBL28181922 | 0.85 | — | — | |
| SCHEMBL1904 | 0.84 | — | — | |
| SCHEMBL2058760 | 0.84 | CA5A (0.46) | TSHRTDP1PTGS1PDE4ATP53 | |
| SCHEMBL126970 | 0.84 | — | — | |
| SCHEMBL27493794 | 0.81 | TSHR (0.40) | TSHRTDP1PTGS1PDE4ACA5A | |
| Methyl Alcohol SCHEMBL23421569 | 0.81 | — | — | |
| SCHEMBL20533683 | 0.81 | — | — | |
| SCHEMBL22581624 | 0.81 | — | — | |
| SCHEMBL20583855 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109081770-A | A kind of preparation method of ortho alkyl phenol | 安阳师范学院 | 2018-12-25 | — | — | CN | claimed |
| CN-105481698-B | A kind of propane diamine of N, N dimethyl 1,3 reclaims the method with the propane diamine of coproduction N, N, N ', N ' tetramethyl 1,3 | 江苏富淼科技股份有限公司 | 2017-06-13 | — | — | CN | claimed |
| CN-110128308-A | Alpha-alkoxy methylene-beta-dicarbonyl compound preparation method | 利尔化学股份有限公司 | 2019-08-16 | — | — | CN | disclosed |
| CN-109081770-A | A kind of preparation method of ortho alkyl phenol | 安阳师范学院 | 2018-12-25 | — | — | CN | disclosed |
| CN-108794365-A | A method of using one pot process selenomethionine | 苏州至善化学有限公司 | 2018-11-13 | — | — | CN | disclosed |
| CN-107995916-A | CURABLE BENZOXAZINE COMPOSITIONS | 亨斯迈先进材料美国有限责任公司 | 2018-05-04 | — | — | CN | disclosed |
| CN-105503884-B | A kind of synthetic method for being used to synthesize the key intermediate of BET protein inhibitors | 上海皓元生物医药科技有限公司 | 2017-10-13 | — | — | CN | disclosed |
| CN-104936962-B | Therapeutically active oxazoline derivatives | UCB生物制药私人有限公司 | 2017-02-22 | — | — | CN | disclosed |
| CN-106046370-A | Oxazoline POZ compound, method for synthesizing the same, and target molecule-POZ conjugate | 塞瑞纳治疗公司 | 2016-10-26 | — | — | CN | disclosed |
| CN-104936962-A | Therapeutically active oxazoline derivatives | UCB PHARMA SA | 2015-09-23 | — | — | CN | disclosed |
| CN-101421297-A | Peptides that block the binding of igg to fcrn | SYNTONIX PHARMACEUTICALS INC (US) | 2009-04-29 | — | — | CN | disclosed |