Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methyl Alcohol SCHEMBL28009509 | 0.84 | RAB9A (0.61) | NPC1RAB9AMEN1KMT2AATM | |
| Formaldehyde SCHEMBL17443195 | 0.84 | MEN1 (0.61) | NPC1RAB9AMEN1KMT2AATM | |
| SCHEMBL29371456 | 0.84 | — | — | |
| SCHEMBL9359592 | 0.84 | MEN1 (0.67) | NPC1RAB9AMEN1KMT2AATM | |
| SCHEMBL15193 | 0.84 | — | — | |
| Formic Acid SCHEMBL27958665 | 0.82 | RAB9A (0.54) | NPC1RAB9AMEN1KMT2AATM | |
| SCHEMBL4365400 | 0.82 | MEN1 (0.58) | NPC1RAB9AMEN1KMT2AATM | |
| SCHEMBL4365922 | 0.82 | RAB9A (0.58) | NPC1RAB9AMEN1KMT2AATM | |
| Iodide SCHEMBL326265 | 0.82 | — | — | |
| Water SCHEMBL9403577 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108610270-B | Bicyano diphenylethylene type two-photon fluorescent solvent chromogenic water-soluble probe and synthetic method and application thereof | 遵义师范学院 | 2020-10-13 | — | — | CN | disclosed |
| CN-106496102-B | Mitochondrial two-photon fluorescence viscosity probe and preparation method thereof | 安徽大学 | 2019-02-05 | — | — | CN | disclosed |
| CN-108610270-A | Dicyanogen methyl isophorone Among two-photon fluorescence solvent adds lustre to water-soluble probe and its synthetic method and application | 遵义师范学院 | 2018-10-02 | — | — | CN | disclosed |
| CN-106496102-A | Mitochondrial two-photon fluorescence viscosity probe and preparation method thereof | 安徽大学 | 2017-03-15 | — | — | CN | disclosed |