Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL40708 | 0.90 | — | — | |
| SCHEMBL28246000 | 0.83 | SMN1; SMN2 (0.35) | — | |
| Piperazine SCHEMBL27841791 | 0.82 | — | — | |
| Pyrrole SCHEMBL28201580 | 0.81 | — | — | |
| Piperazine SCHEMBL28139461 | 0.81 | — | — | |
| SCHEMBL28245243 | 0.81 | HRH2 (0.34) | — | |
| SCHEMBL8865924 | 0.77 | — | — | |
| SCHEMBL28181859 | 0.76 | DPP4 (0.31) | — | |
| SCHEMBL30587626 | 0.76 | — | — | |
| Pyrrolidine SCHEMBL28229892 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109923108-A | Pyridyl-substituted indole compounds | 百时美施贵宝公司 | 2019-06-21 | — | — | CN | claimed |
| CN-109661392-A | For treating the mitochondrial inhibitors of proliferative disorder | 巴斯利尔药物国际股份公司 | 2019-04-19 | — | — | CN | claimed |
| CN-109071548-A | It can be used for treating the pyrroles's benzimidazole derivative or its analog of especially cancer | 埃姆库瑞医药品有限公司 | 2018-12-21 | — | — | CN | claimed |
| CN-104370909-B | Tricyclic compound | ABBVIE 公司 | 2018-09-11 | — | — | CN | claimed |
| CN-108473495-A | Purinones as ubiquitin-specific protease 1 inhibitors | 福马治疗有限公司 | 2018-08-31 | — | — | CN | claimed |
| CN-108473465-A | CGRP receptor antagonist | 赫普塔瑞斯医疗有限公司 | 2018-08-31 | — | — | CN | claimed |
| CN-110139861-A | Pyran derivatives as inhibitors of CYP11A1 (cytochrome P450 monooxygenase 11A1) | 奥赖恩公司 | 2019-08-16 | — | — | CN | disclosed |
| CN-107001271-B | Hydroxyamidine derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2019-05-10 | — | — | CN | disclosed |
| CN-109661392-A | For treating the mitochondrial inhibitors of proliferative disorder | 巴斯利尔药物国际股份公司 | 2019-04-19 | — | — | CN | disclosed |
| CN-109415381-A | Thiazolopyridine derivatives as GPR119 agonist | 人类制药有限公司 | 2019-03-01 | — | — | CN | disclosed |
| CN-109071548-A | It can be used for treating the pyrroles's benzimidazole derivative or its analog of especially cancer | 埃姆库瑞医药品有限公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-109053742-A | New tricyclic compound | ABBVIE 公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-108884043-A | Substituted piperidine compounds and uses thereof | 武田药品工业株式会社 | 2018-11-23 | — | — | CN | disclosed |
| CN-107847765-A | The piperidine derivative of 1,4 substitutions | 赛福伦公司 | 2018-03-27 | — | — | CN | disclosed |
| CN-105408323-B | Piperidines urea derivative | 默克专利股份公司 | 2018-03-13 | — | — | CN | disclosed |
| CN-105358556-B | New compound for selective histone deacetylase inhibitor and the pharmaceutical composition comprising it | 株式会社钟根堂 | 2018-01-02 | — | — | CN | disclosed |
| CN-107428719-A | 4-methylsulfonyl substituted piperidine urea compounds for the treatment of Dilated Cardiomyopathy (DCM) | 迈奥卡迪亚公司 | 2017-12-01 | — | — | CN | disclosed |
| CN-106928203-A | Heterocyclic amides as kinase inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2017-07-07 | — | — | CN | disclosed |
| CN-106573006-A | Heterocyclic amides of RIP1 kinase inhibitors as pharmaceuticals | 葛兰素史密斯克莱知识产权发展有限公司 | 2017-04-19 | — | — | CN | disclosed |
| CN-104177468-B | ANTIOXIDANT INFLAMMATION MODULATORS: OLEANOLIC ACID DERIVATIVES WITH AMINO AND OTHER MODIFICATIONS AT C-17 | 里亚塔医药公司 | 2017-04-12 | — | — | CN | disclosed |