Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | ICMT | O60725 | 1/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28122347 | 0.98 | KCNH3 (0.53) | KCNH3HDAC3HDAC1HDAC2ABL1 | |
| SCHEMBL23630857 | 0.82 | KCNH3 (0.63) | KCNH3HDAC3HDAC1HDAC2ABL1 | |
| SCHEMBL15822970 | 0.82 | KCNH3 (0.63) | KCNH3HDAC3HDAC1HDAC2ABL1 | |
| SCHEMBL12955826 | 0.81 | EPHX1 (0.53) | KCNH3HDAC3GAAALDH1A1HTT | |
| SCHEMBL9738362 | 0.81 | EPHX1 (0.53) | KCNH3HDAC3GAAALDH1A1HTT | |
| SCHEMBL28386850 | 0.81 | EPHX1 (0.53) | KCNH3HDAC3GAAALDH1A1HTT | |
| SCHEMBL1567049 | 0.80 | KCNH3 (0.65) | KCNH3HDAC3HDAC1HDAC2ABL1 | |
| SCHEMBL10916043 | 0.79 | HDAC1 (0.36) | KCNH3HDAC3HDAC1HDAC2ABL1 | |
| SCHEMBL11101285 | 0.79 | MAPT (0.38) | KCNH3HDAC3HDAC1HDAC2ABL1 | |
| SCHEMBL6461214 | 0.79 | EPHX1 (0.50) | KCNH3HDAC3HDAC1HDAC2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103664973-B | Spiro-oxindole compounds and their use as therapeutic agents | 泽农医药公司 | 2017-04-19 | — | — | CN | disclosed |