Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.36 |
| ▸ | HTR2A | P28223 | 4/20 | 0.36 |
| ▸ | HTR2C | P28335 | 4/20 | 0.36 |
| ▸ | HTR2B | P41595 | 4/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SLC22A2 | O15244 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28136163 | 0.77 | ALDH1A1 (0.38) | MEN1KMT2AALDH1A1USP2CDK4 | |
| SCHEMBL28136891 | 0.77 | MEN1 (0.36) | MEN1KMT2AALDH1A1USP2CDK4 | |
| SCHEMBL28144033 | 0.77 | MEN1 (0.36) | MEN1KMT2AALDH1A1USP2CDK4 | |
| SCHEMBL787597 | 0.73 | ALDH1A1 (0.45) | MEN1KMT2AALDH1A1USP2CDK4 | |
| SCHEMBL20952937 | 0.69 | ALDH1A1 (0.40) | MEN1KMT2AALDH1A1USP2CDK4 | |
| SCHEMBL27690393 | 0.68 | NOTUM (0.41) | MEN1KMT2AALDH1A1NOTUMHTR2C | |
| SCHEMBL14337678 | 0.68 | NOTUM (0.42) | MEN1KMT2AALDH1A1NOTUMTP53 | |
| SCHEMBL27935817 | 0.67 | ALDH1A1 (0.47) | MEN1KMT2AALDH1A1USP2CDK4 | |
| SCHEMBL28230721 | 0.66 | ALDH1A1 (0.41) | MEN1KMT2AALDH1A1USP2CDK4 | |
| SCHEMBL27545376 | 0.65 | HSD17B3 (0.35) | MEN1KMT2AALDH1A1NOTUMTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106660998-B | Pyrazolyl-3, 4-dihydroquinolin-2-one aldosterone synthase inhibitors | 豪夫迈·罗氏有限公司 | 2019-10-25 | — | — | CN | disclosed |
| CN-106660998-A | Pyrazolyl-3, 4-dihydroquinolin-2-one aldosterone synthase inhibitors | 豪夫迈·罗氏有限公司 | 2017-05-10 | — | — | CN | disclosed |