Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.58 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.58 |
| ▸ | FLT1 | P17948 | 1/20 | 0.58 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976503 | 0.88 | PDGFRB (0.53) | PDGFRBFGFR1PDGFRAFLT1FGFR3 | |
| SCHEMBL4277099 | 0.87 | MAPT (0.44) | PDGFRBFGFR1PDGFRAFLT1FGFR3 | |
| SCHEMBL7964999 | 0.87 | PDGFRB (0.52) | PDGFRBFGFR1PDGFRAFLT1FGFR3 | |
| SCHEMBL31727099 | 0.85 | PDGFRB (0.60) | PDGFRBFGFR1PDGFRAFLT1FGFR3 | |
| SCHEMBL12359628 | 0.85 | PDGFRB (0.60) | PDGFRBFGFR1PDGFRAFLT1FGFR3 | |
| SCHEMBL10714392 | 0.84 | PDGFRB (0.50) | PDGFRBFGFR1PDGFRAFLT1FGFR3 | |
| SCHEMBL7975215 | 0.84 | PDGFRB (0.50) | PDGFRBFGFR1PDGFRAFLT1FGFR3 | |
| SCHEMBL4423582 | 0.84 | CYP1A2 (0.49) | PDGFRBFGFR1PDGFRAFLT1FGFR3 | |
| SCHEMBL17009935 | 0.84 | CYP1A2 (0.49) | PDGFRBFGFR1PDGFRAFLT1FGFR3 | |
| SCHEMBL28847430 | 0.82 | ALDH1A1 (0.41) | PDGFRBFGFR1PDGFRAFLT1FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108026052-B | 5-hydroxyalkyl benzimidazoles as mIDH1 inhibitors | 德国癌症研究公共权益基金会 | 2021-10-08 | — | — | CN | disclosed |
| CN-107810176-B | N-menthyl benzimidazoles as mIDH1 inhibitors | 德国癌症研究公共权益基金会 | 2020-10-16 | — | — | CN | disclosed |
| CN-106573897-B | Benzimidazol-2-amines as mIDH1 inhibitors | 拜耳制药股份公司 | 2019-09-24 | — | — | CN | disclosed |
| CN-106573897-A | Benzimidazol-2-amines as MiDH1 inhibitors | 拜耳制药股份公司 | 2017-04-19 | — | — | CN | disclosed |