Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | VCP | P55072 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27972345 | 0.85 | RECQL (0.42) | RECQLMAPTALDH1A1SMN1; SMN2VCP | |
| SCHEMBL28405700 | 0.85 | MEN1 (0.40) | RECQLMAPTALDH1A1SMN1; SMN2HTT | |
| SCHEMBL1098698 | 0.84 | MAPT (0.39) | RECQLMAPTALDH1A1SMN1; SMN2HTT | |
| SCHEMBL29739365 | 0.84 | MAPT (0.39) | RECQLMAPTALDH1A1SMN1; SMN2HTT | |
| SCHEMBL28405701 | 0.84 | TSHR (0.41) | RECQLMAPTALDH1A1SMN1; SMN2HTT | |
| SCHEMBL28136377 | 0.84 | ITGB1 (0.40) | ACHEMAPTALDH1A1SMN1; SMN2HTT | |
| SCHEMBL29739370 | 0.79 | MAPT (0.43) | RECQLMAPTALDH1A1SMN1; SMN2HTT | |
| SCHEMBL187546 | 0.77 | ALDH1A1 (0.49) | MAPTALDH1A1HTTESPL1KDM4E | |
| SCHEMBL29739457 | 0.77 | ALDH1A1 (0.49) | MAPTALDH1A1HTTESPL1KDM4E | |
| SCHEMBL3475943 | 0.77 | TDP1 (0.43) | MAPTALDH1A1SMN1; SMN2HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106573897-B | Benzimidazol-2-amines as mIDH1 inhibitors | 拜耳制药股份公司 | 2019-09-24 | — | — | CN | disclosed |
| CN-106573897-A | Benzimidazol-2-amines as MiDH1 inhibitors | 拜耳制药股份公司 | 2017-04-19 | — | — | CN | disclosed |