Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Threonine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 2/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.32 |
| ▸ | PREP | P48147 | 1/20 | 0.32 |
| ▸ | PRCP | P42785 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Threonine SCHEMBL28136712 | 1.00 | NOS2 (0.35) | NOS2NOS3NOS1DPP4DPP8 | |
| Threonine SCHEMBL27803017 | 0.95 | NOS2 (0.38) | NOS2NOS3NOS1DPP4DPP8 | |
| Threonine SCHEMBL7041491 | 0.95 | NOS2 (0.38) | NOS2NOS3NOS1DPP4DPP8 | |
| Threonine SCHEMBL1887229 | 0.95 | NOS2 (0.38) | NOS2NOS3NOS1DPP4DPP8 | |
| Threonine SCHEMBL28397150 | 0.95 | NOS2 (0.38) | NOS2NOS3NOS1DPP4DPP8 | |
| Threonine SCHEMBL28236094 | 0.95 | NOS2 (0.38) | NOS2NOS3NOS1DPP4DPP8 | |
| Threonine SCHEMBL1887225 | 0.95 | NOS2 (0.38) | NOS2NOS3NOS1DPP4DPP8 | |
| Threonine SCHEMBL25330687 | 0.93 | NOS2 (0.36) | NOS2NOS3NOS1DPP4DPP8 | |
| Threonine SCHEMBL6684384 | 0.93 | NOS2 (0.36) | NOS2NOS3NOS1DPP4DPP8 | |
| Threonine SCHEMBL11969543 | 0.89 | NOS2 (0.33) | NOS2NOS3NOS1DPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106535913-A | Stable compositions of neuroactive peptides | 诺雷克斯股份有限公司 | 2017-03-22 | — | — | CN | disclosed |