SCHEMBL28138372

SCHEMBL28138372

CC(=O)Cc1cccc(Cl)c1.Cc1c(C(=O)O)cccc1C(=O)O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTBP2 P56545 1/20 0.50
APEX1 P27695 1/20 0.48
PIK3CA P42336 1/20 0.47
MRGPRX4 Q96LA9 1/20 0.46
HTR3E A5X5Y0 1/20 0.44
HTR3B O95264 1/20 0.44
HTR3A P46098 1/20 0.44
HTR3D Q70Z44 1/20 0.44
HTR3C Q8WXA8 1/20 0.44
NOTUM Q6P988 1/20 0.43
KMT2A Q03164 3/20 0.43
MEN1 O00255 2/20 0.43
ALDH1A1 P00352 2/20 0.43
CSNK1D P48730 1/20 0.43
HPGD P15428 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
RXRA P19793 1/20 0.43
RXRB P28702 1/20 0.43
RXRG P48443 1/20 0.43
MAOA P21397 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL201554 0.86 CTBP2 (0.59) CTBP2PIK3CAHTR3EHTR3BHTR3A
SCHEMBL27675921 0.84 ALDH1A1 (0.52) KMT2AMEN1ALDH1A1HPGDSMN1; SMN2
SCHEMBL28016999 0.78 SMN1; SMN2 (0.47) CTBP2KMT2AMEN1ALDH1A1HPGD
Chlorobenzene SCHEMBL28138967 0.77 ALDH1A1 (0.54) MRGPRX4NOTUMKMT2AMEN1ALDH1A1
Chlorobenzene SCHEMBL28300627 0.77 CTBP2 (0.53) CTBP2KMT2AMEN1ALDH1A1HPGD
SCHEMBL2302284 0.76 AOC3 (0.51) CTBP2PIK3CAHTR3EHTR3BHTR3A
SCHEMBL28138970 0.76 KMT2A (0.47) CTBP2KMT2AMEN1ALDH1A1HPGD
SCHEMBL28138354 0.76 ALDH1A1 (0.46) KMT2AMEN1ALDH1A1SMN1; SMN2PTGER1
SCHEMBL27544556 0.76 MYC (0.52) MRGPRX4NOTUMKMT2AMEN1ALDH1A1
SCHEMBL467923 0.73 CTBP2 (0.66) CTBP2PIK3CAHTR3EHTR3BHTR3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104710256-B Cheap and efficient synthesis method of alpha-hydroxyketone compound 北京大学 2017-03-22 CN disclosed