Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acepromazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 6/20 | 1.00 |
| ▸ | DRD3 known ✓ | P35462 | 6/20 | 1.00 |
| ▸ | HTR2A known ✓ | P28223 | 4/20 | 0.69 |
| ▸ | DRD4 known ✓ | P21917 | 2/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 11/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 10/20 | 1.00 |
| ▸ | HTR1A | P08908 | 7/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 6/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 6/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 6/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 6/20 | 1.00 |
| ▸ | LMNA | P02545 | 6/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 5/20 | 1.00 |
| ▸ | DRD1 | P21728 | 5/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 5/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 5/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 1.00 |
| ▸ | TSHR | P16473 | 4/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 4/20 | 1.00 |
| ▸ | PRNP | P04156 | 3/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acepromazine SCHEMBL29582179 | 1.00 | CYP2D6 (1.00) | CYP2D6CYP1A2HTR1ADRD2SLC6A2 | |
| Acepromazine SCHEMBL73018 | 1.00 | CYP2D6 (1.00) | CYP2D6CYP1A2HTR1ADRD2SLC6A2 | |
| Acepromazine SCHEMBL29441481 | 1.00 | CYP2D6 (1.00) | CYP2D6CYP1A2HTR1ADRD2SLC6A2 | |
| Acepromazine SCHEMBL30620438 | 0.94 | CYP2D6 (0.88) | CYP2D6CYP1A2HTR1ADRD2SLC6A2 | |
| Acepromazine SCHEMBL21803694 | 0.94 | CYP2D6 (0.88) | CYP2D6CYP1A2HTR1ADRD2SLC6A2 | |
| Acepromazine SCHEMBL29876174 | 0.94 | CYP2D6 (0.88) | CYP2D6CYP1A2HTR1ADRD2SLC6A2 | |
| Acepromazine SCHEMBL30616039 | 0.94 | CYP2D6 (0.88) | CYP2D6CYP1A2HTR1ADRD2SLC6A2 | |
| Acepromazine SCHEMBL204733 | 0.94 | CYP2D6 (0.88) | CYP2D6CYP1A2HTR1ADRD2SLC6A2 | |
| Acepromazine SCHEMBL7253707 | 0.94 | CYP2D6 (0.88) | CYP2D6CYP1A2HTR1ADRD2SLC6A2 | |
| Acepromazine SCHEMBL204734 | 0.94 | CYP2D6 (0.88) | CYP2D6CYP1A2HTR1ADRD2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |