Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | PRKACA | P17612 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | DUSP10 | Q9Y6W6 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | ASIC3 | Q9UHC3 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10272516 | 0.78 | AURKA (0.53) | HSP90AA1AURKAPRKACAADORA2ADUSP10 | |
| SCHEMBL4447801 | 0.75 | BPTF (0.54) | HSP90AA1AURKAPRKACAADORA2ADUSP10 | |
| SCHEMBL4101556 | 0.75 | ADORA2A (0.50) | HSP90AA1AURKAPRKACAADORA2ADUSP10 | |
| SCHEMBL1514690 | 0.74 | HSP90AA1 (0.58) | HSP90AA1AURKAPRKACAADORA2ADUSP10 | |
| SCHEMBL8703546 | 0.74 | AURKA (0.53) | HSP90AA1AURKAPRKACAADORA2ADUSP10 | |
| SCHEMBL28145717 | 0.74 | HSP90AA1 (0.53) | HSP90AA1AURKAPRKACAADORA2ADUSP10 | |
| SCHEMBL3970473 | 0.74 | AURKA (0.53) | HSP90AA1AURKAPRKACAADORA2ADUSP10 | |
| SCHEMBL27293910 | 0.73 | HSP90AA1 (0.49) | HSP90AA1AURKAPRKACAADORA2ADUSP10 | |
| SCHEMBL27997667 | 0.73 | HSP90AA1 (0.49) | HSP90AA1AURKAPRKACAADORA2ADUSP10 | |
| SCHEMBL28144742 | 0.73 | AURKA (0.49) | HSP90AA1AURKAPRKACAADORA2ADUSP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106794161-A | TrkA kinase inhibitors, composition and its method | 默沙东公司 | 2017-05-31 | — | — | CN | disclosed |