Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2R | P25116 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 4/20 | 0.42 |
| ▸ | KCNK9 | Q9NPC2 | 4/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27574540 | 0.83 | IRAK4 (0.43) | F2RMEN1NR1I2LMNACHRM2 | |
| SCHEMBL16960407 | 0.83 | F2R (0.40) | F2RKCNK3KCNK9HCRTR1HCRTR2 | |
| SCHEMBL28152797 | 0.82 | MEN1 (0.43) | MEN1NR1I2LMNACHRM2CYP3A4 | |
| SCHEMBL1135994 | 0.81 | CTSD (0.49) | MEN1NR1I2LMNACHRM2CYP3A4 | |
| SCHEMBL18935479 | 0.80 | F2R (0.38) | F2RSLC6A3KCNK3KCNK9SCN9A | |
| SCHEMBL16829425 | 0.80 | MEN1 (0.49) | MEN1NR1I2LMNACHRM2CYP3A4 | |
| SCHEMBL28192692 | 0.80 | KCNK3 (0.45) | F2RCYP3A4OPRK1KCNK3KCNK9 | |
| SCHEMBL28348750 | 0.79 | MEN1 (0.44) | F2RMEN1KMT2AHDAC6KCNK3 | |
| SCHEMBL16951289 | 0.79 | F2R (0.38) | F2RSLC6A3KCNK3KCNK9HCRTR1 | |
| SCHEMBL29710969 | 0.79 | CTNNB1 (0.55) | F2RMEN1NR1I2LMNACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106661035-A | Pyrazolopyrimidine derivatives as inhibitors of bruton's tyrosine kinase | 莱德克斯制药公共有限公司 | 2017-05-10 | — | — | CN | disclosed |