Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.56 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.52 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.52 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.52 |
| ▸ | F7 | P08709 | 1/20 | 0.52 |
| ▸ | F3 | P13726 | 1/20 | 0.52 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.52 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.52 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.52 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.52 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | NNMT | P40261 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL503242 | 0.97 | — | — | |
| Hydrochloric Acid SCHEMBL25242562 | 0.95 | HCAR2 (0.56) | HCAR2SIRT2SIRT1SIRT3F7 | |
| Water SCHEMBL27583249 | 0.95 | HCAR2 (0.56) | HCAR2SIRT2SIRT1SIRT3F7 | |
| SCHEMBL27541990 | 0.95 | — | — | |
| Hydrochloric Acid SCHEMBL12971394 | 0.95 | HCAR2 (0.56) | HCAR2SIRT2SIRT1SIRT3F7 | |
| SCHEMBL27941587 | 0.95 | HCAR2 (0.56) | HCAR2SIRT2SIRT1SIRT3F7 | |
| Hydrochloric Acid SCHEMBL28749975 | 0.92 | HCAR2 (0.54) | HCAR2SIRT2SIRT1SIRT3F7 | |
| Sulfuric Acid SCHEMBL27952916 | 0.88 | HCAR2 (0.50) | HCAR2SIRT2SIRT1SIRT3F7 | |
| Formic Acid SCHEMBL25244373 | 0.88 | HCAR2 (0.50) | HCAR2SIRT2SIRT1SIRT3F7 | |
| SCHEMBL27941661 | 0.84 | HCAR2 (0.46) | HCAR2SIRT2SIRT1SIRT3F7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109923117-A | Use the combination therapy of the phosphoinositide 3-kinase inhibitor with zinc bound fraction | 柯瑞斯公司 | 2019-06-21 | — | — | CN | disclosed |
| CN-105461736-B | Inhibitors of phosphatidylinositol3 3-kinase with zinc bound site | 柯瑞斯公司 | 2018-06-12 | — | — | CN | disclosed |
| CN-104292242-B | Pyrantel compound and preparation, as well as preparation method and application of pyrantel compound and preparation | 广州必贝特医药技术有限公司 | 2017-05-17 | — | — | CN | disclosed |
| CN-105461736-A | PHOSPHOINOSITIDE 3-KINASE INHIBITOR WITH A ZINC BINDING MOIETY | CURIS INC | 2016-04-06 | — | — | CN | disclosed |
| CN-103582483-B | Phosphatidylinositol 3-kinase inhibitors with zinc binding sites | CURIS, INC. (US) | 2016-02-17 | — | — | CN | disclosed |
| CN-103582483-A | Phosphatidylinositol 3-kinase inhibitors with zinc binding sites | CURIS INC | 2014-02-12 | — | — | CN | disclosed |