Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.55 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.53 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.49 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | CDK1 | P06493 | 2/20 | 0.41 |
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | PRKACA | P17612 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30711433 | 1.00 | TNF (0.55) | TNFPRKCZHASPINRPS6KA3NOTUM | |
| SCHEMBL29501875 | 0.83 | PRKCZ (0.72) | TNFPRKCZAURKBCYP1A2CYP3A4 | |
| SCHEMBL6243938 | 0.83 | PRKCZ (0.72) | TNFPRKCZAURKBCYP1A2CYP3A4 | |
| SCHEMBL6998015 | 0.82 | TNF (0.73) | TNFPRKCZHASPINSLC22A12CYP1A2 | |
| SCHEMBL12074301 | 0.80 | PRKCZ (0.73) | TNFPRKCZAURKBCYP1A2CYP3A4 | |
| SCHEMBL12074747 | 0.79 | TNF (0.69) | TNFPRKCZHASPINNOTUMSLC22A12 | |
| SCHEMBL9824826 | 0.78 | TNF (0.58) | TNFPRKCZHASPINNOTUMKDM4C | |
| SCHEMBL30911309 | 0.77 | CYP11B1 (0.64) | PRKCZSLC22A12CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL27404900 | 0.77 | CYP11B1 (0.64) | PRKCZSLC22A12CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL17691562 | 0.77 | KDM4E (0.50) | TNFPRKCZHASPINRPS6KA3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105153156-B | A kind of naphthyridines 1 of 4 phenyl 2,7（2H）The preparation method of ketone | 徐峰 | 2017-07-28 | — | — | CN | claimed |
| CN-105153156-B | A kind of naphthyridines 1 of 4 phenyl 2,7（2H）The preparation method of ketone | 徐峰 | 2017-07-28 | — | — | CN | disclosed |