Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | ACE | P12821 | 1/20 | 0.33 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.32 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.32 |
| ▸ | HRH2 | P25021 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | CMA1 | P23946 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | REN | P00797 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2814776 | 1.00 | PROKR1 (0.37) | PROKR1CNR2KLK5PABPC1FPR2 | |
| SCHEMBL7902566 | 0.93 | PROKR1 (0.38) | PROKR1CNR2KLK5PABPC1ACE | |
| SCHEMBL7893430 | 0.93 | USP30 (0.36) | PROKR1CNR2KLK5PABPC1FPR2 | |
| SCHEMBL2788344 | 0.93 | PROKR1 (0.38) | PROKR1CNR2KLK5PABPC1ACE | |
| SCHEMBL7897770 | 0.91 | PROKR1 (0.37) | PROKR1CNR2KLK5PABPC1ACE | |
| SCHEMBL7891211 | 0.89 | PROKR1 (0.42) | PROKR1CNR2KLK5ACEPADI4 | |
| SCHEMBL7899697 | 0.89 | PROKR1 (0.39) | PROKR1CNR2KLK5FPR2ACE | |
| SCHEMBL2790426 | 0.87 | PROKR1 (0.42) | PROKR1CNR2FPR2ITGB1ITGA4 | |
| SCHEMBL2790427 | 0.87 | PROKR1 (0.42) | PROKR1CNR2FPR2ITGB1ITGA4 | |
| SCHEMBL2814433 | 0.87 | PROKR1 (0.39) | PROKR1CNR2KLK5ACEPADI4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |