Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.39 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | PER2 | O15055 | 1/20 | 0.33 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.33 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7891211 | 0.93 | PROKR1 (0.42) | PROKR1KLK5CNR2ACEHRH2 | |
| SCHEMBL7902566 | 0.92 | PROKR1 (0.38) | PROKR1KLK5CNR2ACEHRH2 | |
| SCHEMBL2789222 | 0.92 | PROKR1 (0.41) | PROKR1CNR2PER2CRY1CRY2 | |
| SCHEMBL2788383 | 0.91 | KLK5 (0.36) | KLK5CNR2CACNA1BACEHRH2 | |
| SCHEMBL2814433 | 0.91 | PROKR1 (0.39) | PROKR1KLK5CNR2ACEHRH2 | |
| SCHEMBL7901932 | 0.91 | PTGS2 (0.34) | KLK5CNR2CACNA1BHRH2HRH1 | |
| SCHEMBL2814434 | 0.91 | PROKR1 (0.39) | PROKR1KLK5CNR2ACEHRH2 | |
| SCHEMBL7897770 | 0.90 | PROKR1 (0.37) | PROKR1KLK5CNR2ACEHRH2 | |
| SCHEMBL2788344 | 0.90 | PROKR1 (0.38) | PROKR1KLK5CNR2ACEHRH2 | |
| SCHEMBL7905913 | 0.90 | CACNA1B (0.35) | KLK5CACNA1BACEHRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |