Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.55 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.55 |
| ▸ | PLK1 | P53350 | 1/20 | 0.54 |
| ▸ | CTSK | P43235 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8891644 | 0.95 | MAPT (0.60) | SMN1; SMN2MAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2815273 | 0.88 | MRGPRX4 (0.71) | SMN1; SMN2MAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2063068 | 0.86 | SMN1; SMN2 (0.73) | SMN1; SMN2MAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2801658 | 0.85 | MAPT (0.72) | SMN1; SMN2MAPTCYP1A2CYP3A4CYP2C9 | |
| Bicarbonate SCHEMBL5499350 | 0.83 | SMN1; SMN2 (0.68) | SMN1; SMN2MAPTCYP1A2CYP3A4CYP2C9 | |
| Bicarbonate SCHEMBL5499351 | 0.83 | SMN1; SMN2 (0.68) | SMN1; SMN2MAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8889267 | 0.82 | MRGPRX4 (0.64) | SMN1; SMN2HPGDNPC1RAB9AMRGPRX4 | |
| SCHEMBL17835555 | 0.82 | MAPT (0.57) | SMN1; SMN2MAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL17129585 | 0.82 | MAPT (0.67) | SMN1; SMN2MAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2188210 | 0.81 | SMPD1 (0.76) | SMN1; SMN2MAPTCYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100249123-A1 | NOVEL BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE | ADDEX PHARMA SA (CH) | 2010-09-30 | — | — | US | disclosed |
| EP-2134676-A2 | NOVEL BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE | Addex Pharma SA (CH) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008117175-A2 | NOVEL BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE | ADDEX PHARMA SA (CH) | 2008-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249123-A1 | NOVEL BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE | FSHR, GNRHR, SHBG | SMN1; SMN2 4686/4885MAPT 4813/4885CYP1A2 704/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.