Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.44 |
| ▸ | CA1 | P00915 | 10/20 | 0.41 |
| ▸ | CA2 | P00918 | 10/20 | 0.41 |
| ▸ | CA9 | Q16790 | 3/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28151083 | 0.86 | CA1 (0.49) | HRH4CA1CA2CA9TLR8 | |
| SCHEMBL28151134 | 0.86 | HRH4 (0.51) | HRH4TLR8 | |
| SCHEMBL17315427 | 0.82 | NUDT1 (0.51) | HRH4CA1CA2CA9TLR8 | |
| SCHEMBL28152159 | 0.82 | HRH4 (0.47) | HRH4CA1CA2CA9TLR8 | |
| SCHEMBL28151132 | 0.81 | CA1 (0.56) | HRH4CA1CA2CA9CA12 | |
| SCHEMBL28845276 | 0.79 | HRH4 (0.43) | HRH4CA1CA2CA9TLR8 | |
| SCHEMBL28152251 | 0.78 | CA1 (0.55) | CA1CA2CA9CA12CA7 | |
| SCHEMBL28151149 | 0.78 | HRH4 (0.64) | HRH4TLR8 | |
| SCHEMBL28043727 | 0.75 | HRH4 (0.56) | HRH4TLR8 | |
| SCHEMBL28043930 | 0.75 | HRH4 (0.55) | HRH4TLR8SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106794181-A | MTH1 inhibitors for the treatment of inflammatory and autoimmune conditions | 托马斯·黑勒戴药物研究基金会 | 2017-05-31 | — | — | CN | disclosed |