Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | UCHL1 | P09936 | 3/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SCN4A | P35499 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16824577 | 1.00 | HSD17B10 (0.47) | HSD17B10SMN1; SMN2NPC1UCHL1NR1H2 | |
| SCHEMBL16824578 | 1.00 | HSD17B10 (0.47) | HSD17B10SMN1; SMN2NPC1UCHL1NR1H2 | |
| SCHEMBL19390030 | 0.88 | NPC1 (0.41) | HSD17B10SMN1; SMN2NPC1UCHL1NR1H2 | |
| SCHEMBL8244248 | 0.88 | HSD17B10 (0.41) | HSD17B10SMN1; SMN2NPC1UCHL1NR1H2 | |
| SCHEMBL23864595 | 0.86 | NPC1 (0.41) | HSD17B10SMN1; SMN2NPC1UCHL1NR1H2 | |
| SCHEMBL206317 | 0.86 | HSD17B10 (0.42) | HSD17B10SMN1; SMN2NPC1LMNANPSR1 | |
| SCHEMBL571200 | 0.86 | HSD17B10 (0.42) | HSD17B10SMN1; SMN2NPC1LMNANPSR1 | |
| SCHEMBL31482666 | 0.85 | NR1H2 (0.45) | HSD17B10SMN1; SMN2NPC1UCHL1NR1H2 | |
| SCHEMBL18084466 | 0.85 | NR1H2 (0.45) | HSD17B10SMN1; SMN2NPC1UCHL1NR1H2 | |
| SCHEMBL26981387 | 0.85 | NR1H2 (0.45) | HSD17B10SMN1; SMN2NPC1UCHL1NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106928127-B | Substituted piperidine amide derivative, preparation method and pharmaceutical application thereof | 四川海思科制药有限公司 | 2021-07-16 | — | — | CN | disclosed |
| CN-106928127-A | Substituted piperidine class amide derivatives and preparation method thereof and application pharmaceutically | 四川海思科制药有限公司 | 2017-07-07 | — | — | CN | disclosed |