Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.75 |
| ▸ | GAA | P10253 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | CA1 | P00915 | 4/20 | 0.52 |
| ▸ | CA2 | P00918 | 4/20 | 0.52 |
| ▸ | CA9 | Q16790 | 4/20 | 0.52 |
| ▸ | CA7 | P43166 | 3/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethoxycarbonyl Group SCHEMBL27849884 | 0.87 | ALDH1A1 (0.58) | MAPTALDH1A1GAALMNASMN1; SMN2 | |
| SCHEMBL1959129 | 0.83 | MAPT (0.75) | MAPTALDH1A1GAALMNASMN1; SMN2 | |
| SCHEMBL16038620 | 0.83 | MAPT (0.75) | MAPTALDH1A1GAALMNASMN1; SMN2 | |
| SCHEMBL14377101 | 0.81 | MAPT (0.57) | MAPTALDH1A1GAALMNASMN1; SMN2 | |
| SCHEMBL20876774 | 0.80 | GAA (0.72) | MAPTALDH1A1GAALMNASMN1; SMN2 | |
| SCHEMBL3620269 | 0.79 | MAPT (0.77) | MAPTALDH1A1GAALMNASMN1; SMN2 | |
| SCHEMBL3923062 | 0.78 | ALDH1A1 (0.58) | MAPTALDH1A1GAALMNASMN1; SMN2 | |
| SCHEMBL7420552 | 0.78 | MAPT (0.55) | MAPTALDH1A1GAALMNASMN1; SMN2 | |
| SCHEMBL14000134 | 0.78 | ALDH1A1 (0.58) | MAPTALDH1A1GAALMNASMN1; SMN2 | |
| SCHEMBL31337422 | 0.78 | MAPT (0.55) | MAPTALDH1A1GAALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108175749-A | The solid dispersions of melt extrusion containing cell death inducer | 艾伯维爱尔兰无限公司 | 2018-06-19 | — | — | CN | disclosed |
| CN-103282025-B | Melt-extruded solid dispersions containing apoptosis-inducing agents | 艾伯维爱尔兰无限公司 | 2018-01-02 | — | — | CN | disclosed |
| CN-104876927-B | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases | 艾伯维爱尔兰无限公司 | 2017-06-23 | — | — | CN | disclosed |