Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.56 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18485519 | 1.00 | LMNA (0.67) | LMNANPSR1NPC1MEN1KMT2A | |
| SCHEMBL18487506 | 0.96 | LMNA (0.63) | LMNANPSR1NPC1MEN1KMT2A | |
| SCHEMBL31515502 | 0.96 | LMNA (0.63) | LMNANPSR1NPC1MEN1KMT2A | |
| SCHEMBL11987662 | 0.87 | NPSR1 (0.76) | LMNANPSR1NPC1MEN1KMT2A | |
| SCHEMBL28153125 | 0.86 | LMNA (0.65) | LMNANPSR1NPC1MEN1KMT2A | |
| SCHEMBL28153267 | 0.86 | LMNA (0.54) | LMNANPSR1NPC1MEN1KMT2A | |
| SCHEMBL28152032 | 0.85 | LMNA (0.50) | LMNANPSR1NPC1MEN1KMT2A | |
| SCHEMBL28151960 | 0.85 | LMNA (0.50) | LMNANPSR1NPC1MEN1KMT2A | |
| SCHEMBL28152029 | 0.85 | LMNA (0.50) | LMNANPSR1NPC1MEN1KMT2A | |
| SCHEMBL28151955 | 0.84 | LMNA (0.48) | LMNANPSR1NPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106928126-B | Amide derivative, preparation method and pharmaceutical application thereof | 四川海思科制药有限公司 | 2019-12-20 | — | — | CN | disclosed |
| CN-106928126-A | A kind of amide derivatives and preparation method thereof and application pharmaceutically | 四川海思科制药有限公司 | 2017-07-07 | — | — | CN | disclosed |