SCHEMBL28159595

SCHEMBL28159595

Brc1cc2ccc(-c3ccccc3)cc2[nH]1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FGFR1 P11362 1/20 0.49
NPC1 O15118 2/20 0.47
KDM4E B2RXH2 1/20 0.42
MEN1 O00255 1/20 0.42
GAA P10253 1/20 0.42
MAPT P10636 1/20 0.42
KMT2A Q03164 1/20 0.42
CDK4 P11802 2/20 0.42
CCND1 P24385 2/20 0.42
ALDH1A1 P00352 1/20 0.41
MAPK1 P28482 1/20 0.41
ESR1 P03372 2/20 0.41
ESR2 Q92731 2/20 0.41
RAB9A P51151 1/20 0.41
TNKS2 Q9H2K2 1/20 0.41
DYRK3 O43781 1/20 0.41
CLK1 P49759 1/20 0.41
CLK2 P49760 1/20 0.41
CLK3 P49761 1/20 0.41
GSK3B P49841 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5130538 0.78 NPC1 (0.68) FGFR1NPC1KDM4EMEN1MAPT
SCHEMBL28280447 0.77 FGFR1 (0.49) FGFR1NPC1KDM4EMEN1GAA
SCHEMBL27290615 0.77 ESR2 (0.50) FGFR1NPC1KDM4EMEN1GAA
SCHEMBL28281112 0.77 FGFR1 (0.49) FGFR1NPC1KDM4EMEN1GAA
SCHEMBL13541757 0.77 TNKS2 (0.49) FGFR1NPC1KDM4EMEN1GAA
SCHEMBL3591265 0.74 AOC3 (0.54) NPC1KDM4EMEN1GAAMAPT
SCHEMBL261138 0.74 AOC3 (0.54) NPC1KDM4EMEN1GAAMAPT
SCHEMBL27618858 0.74 AOC3 (0.54) NPC1KDM4EMEN1GAAMAPT
SCHEMBL29425617 0.74 AOC3 (0.54) NPC1KDM4EMEN1GAAMAPT
SCHEMBL27805572 0.73 CA12 (0.59) FGFR1NPC1KDM4EMEN1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107021968-B The method of the polysubstituted organic photochemical catalyst catalyzing indole quinoline class compound oxidation dehydrogenation synthesis of indole class compound of BODIPY 陕西师范大学 2018-12-07 CN disclosed
CN-107021968-A The method of the polysubstituted organic photochemical catalyst catalyzing indole quinoline class compound oxidation dehydrogenation synthesis of indole class compounds of BODIPY 陕西师范大学 2017-08-08 CN disclosed