Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 13/20 | 0.44 |
| ▸ | HTR2C | P28335 | 12/20 | 0.44 |
| ▸ | HTR2B | P41595 | 12/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | KDM1A | O60341 | 4/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19200494 | 1.00 | HTR2A (0.44) | HTR2AHTR2CHTR2BHRH3SIGMAR1 | |
| SCHEMBL17571679 | 1.00 | HTR2A (0.44) | HTR2AHTR2CHTR2BHRH3SIGMAR1 | |
| SCHEMBL17571730 | 1.00 | HTR2A (0.44) | HTR2AHTR2CHTR2BHRH3SIGMAR1 | |
| SCHEMBL20678607 | 0.81 | SIGMAR1 (0.39) | HTR2AHTR2CHTR2BHRH3SIGMAR1 | |
| SCHEMBL5907844 | 0.81 | SIGMAR1 (0.39) | HTR2AHTR2CHTR2BHRH3SIGMAR1 | |
| SCHEMBL1941901 | 0.80 | KDM1A (0.37) | HTR2AHTR2CHTR2BHRH3SIGMAR1 | |
| SCHEMBL17571758 | 0.78 | HTR2A (0.46) | HTR2AHTR2CHTR2BHRH3SIGMAR1 | |
| SCHEMBL18161259 | 0.78 | HTR2A (0.46) | HTR2AHTR2CHTR2BHRH3SIGMAR1 | |
| SCHEMBL17835702 | 0.77 | HTR2A (0.44) | HTR2AHTR2CHTR2BHRH3SIGMAR1 | |
| SCHEMBL17559139 | 0.77 | HTR2A (0.44) | HTR2AHTR2CHTR2BHRH3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107074824-B | Phthalazine derivatives of formula (I) as PCAF and GCN5 inhibitors for the treatment of cancer | 基因泰克公司 | 2021-01-08 | — | — | CN | disclosed |
| CN-107074824-A | Phthalazine derivatives of formula (I) as PCAF and GCN5 inhibitors for the treatment of cancer | 基因泰克公司 | 2017-08-18 | — | — | CN | disclosed |