SCHEMBL28164029

SCHEMBL28164029

c1ccc(-c2cccc(-c3ccsc3)c2)cc1

nearest known ligand 0.82

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 3/20 0.82
CYP2B6 P20813 2/20 0.82
CYP2E1 P05181 1/20 0.82
PRMT6 Q96LA8 1/20 0.53
PTPRC P08575 1/20 0.50
KCNH2 Q12809 1/20 0.50
GLO1 Q04760 1/20 0.49
CYP3A4 P08684 1/20 0.48
CYP2C9 P11712 1/20 0.48
CYP2C19 P33261 1/20 0.48
KAT6A Q92794 1/20 0.47
ACMSD Q8TDX5 1/20 0.46
PDGFRB P09619 1/20 0.46
PDGFRA P16234 1/20 0.46
CDK8 P49336 1/20 0.44
CNR1 P21554 1/20 0.44
MAOA P21397 1/20 0.43
KMO O15229 1/20 0.42
ALOX5 P09917 1/20 0.42
ERN1 O75460 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4350314 0.93 CYP2A6 (0.68) CYP2A6CYP2B6CYP2E1PRMT6PTPRC
SCHEMBL149952 0.91 CYP2A6 (1.00) CYP2A6CYP2B6CYP2E1PRMT6PTPRC
SCHEMBL24106775 0.88 CYP2A6 (0.95) CYP2A6CYP2B6CYP2E1PRMT6PTPRC
SCHEMBL3997707 0.88
SCHEMBL5713686 0.81 CYP2A6 (0.54) CYP2A6CYP2B6CYP2E1PRMT6PTPRC
SCHEMBL5477270 0.79 CYP2A6 (0.69) CYP2A6CYP2B6CYP2E1PRMT6PTPRC
SCHEMBL18002045 0.79 CYP2A6 (0.62) CYP2A6CYP2B6CYP2E1PTPRCGLO1
SCHEMBL17004981 0.79 CYP2A6 (0.70) CYP2A6CYP2B6CYP2E1PRMT6PTPRC
SCHEMBL27811941 0.78 CYP2A6 (0.75) CYP2A6CYP2B6CYP2E1PRMT6PTPRC
Hydrogen Sulfide SCHEMBL28154356 0.78 CYP2A6 (0.75) CYP2A6CYP2B6CYP2E1PRMT6PTPRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106946808-A The synthetic method of benzo [1,3,5] triazole octanone derivative 苏州大学 2017-07-14 CN disclosed