Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 7/20 | 0.41 |
| ▸ | LCK | P06239 | 6/20 | 0.41 |
| ▸ | SIK2 | Q9H0K1 | 6/20 | 0.41 |
| ▸ | SIK3 | Q9Y2K2 | 6/20 | 0.41 |
| ▸ | SIK1 | P57059 | 4/20 | 0.41 |
| ▸ | KIT | P10721 | 6/20 | 0.40 |
| ▸ | SRC | P12931 | 5/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | FYN | P06241 | 2/20 | 0.40 |
| ▸ | YES1 | P07947 | 2/20 | 0.40 |
| ▸ | LYN | P07948 | 2/20 | 0.40 |
| ▸ | HCK | P08631 | 2/20 | 0.40 |
| ▸ | BCR | P11274 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | FGR | P09769 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27792012 | 0.85 | LCK (0.42) | ABL1LCKSIK2SIK3SIK1 | |
| SCHEMBL17029102 | 0.80 | CHRNA7 (0.38) | ABL1LCKSIK2SIK3SIK1 | |
| SCHEMBL4254834 | 0.77 | LCK (0.52) | ABL1LCKSIK2SIK3SIK1 | |
| SCHEMBL20633817 | 0.77 | RAB9A (0.52) | ABL1LCKSIK2SIK3SIK1 | |
| SCHEMBL12445981 | 0.77 | LCK (0.52) | ABL1LCKSIK2SIK3SIK1 | |
| SCHEMBL4594178 | 0.76 | KDR (0.52) | CHRNA7 | |
| SCHEMBL4254631 | 0.75 | ABL1 (0.50) | ABL1LCKSIK2SIK3SIK1 | |
| SCHEMBL22964566 | 0.75 | LCK (0.56) | ABL1LCKSIK2SIK3SIK1 | |
| SCHEMBL21495194 | 0.75 | SIK2 (0.48) | ABL1LCKSIK2SIK3SIK1 | |
| SCHEMBL27792010 | 0.74 | LCK (0.42) | ABL1LCKSIK2SIK3SIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107043375-B | Novel method for preparing dasatinib and intermediate thereof | 江苏食品药品职业技术学院 | 2020-03-20 | — | — | CN | claimed |
| CN-107043375-B | Novel method for preparing dasatinib and intermediate thereof | 江苏食品药品职业技术学院 | 2020-03-20 | — | — | CN | disclosed |
| CN-107043375-A | A kind of new method for preparing Dasatinib and its intermediate | 江苏食品药品职业技术学院 | 2017-08-15 | — | — | CN | disclosed |