Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | PARP1 | P09874 | 1/20 | 0.56 |
| ▸ | NR2E1 | Q9Y466 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | HTR5A | P47898 | 1/20 | 0.50 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30160092 | 0.89 | KDM4E (0.73) | KDM4EALDH1A1SMN1; SMN2HTR2AHTR2C | |
| SCHEMBL104598 | 0.89 | KDM4E (0.73) | KDM4EALDH1A1SMN1; SMN2HTR2AHTR2C | |
| Bromide SCHEMBL8568783 | 0.88 | KDM4E (0.71) | KDM4EALDH1A1SMN1; SMN2HTR2AHTR2C | |
| SCHEMBL14156164 | 0.88 | SMN1; SMN2 (0.74) | KDM4EALDH1A1SMN1; SMN2HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL5776419 | 0.88 | KDM4E (0.71) | KDM4EALDH1A1SMN1; SMN2HTR2AHTR2C | |
| SCHEMBL15266076 | 0.88 | KDM4E (0.71) | KDM4EALDH1A1SMN1; SMN2HTR2AHTR2C | |
| Iodide SCHEMBL8569085 | 0.88 | KDM4E (0.71) | KDM4EALDH1A1SMN1; SMN2HTR2AHTR2C | |
| SCHEMBL30657796 | 0.88 | SMN1; SMN2 (0.74) | KDM4EALDH1A1SMN1; SMN2HTR2AHTR2C | |
| SCHEMBL11641810 | 0.88 | SMN1; SMN2 (0.74) | KDM4EALDH1A1SMN1; SMN2HTR2AHTR2C | |
| SCHEMBL7402531 | 0.88 | KDM4E (0.71) | KDM4EALDH1A1SMN1; SMN2HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105358546-B | The tetrahydro carbazole being substituted and carbazole carboxamide compounds useful as kinase inhibitor | 百时美施贵宝公司 | 2017-10-31 | — | — | CN | disclosed |
| CN-107108555-A | Three ring atropisomer compounds | 百时美施贵宝公司 | 2017-08-29 | — | — | CN | disclosed |
| CN-107074804-A | Carbazole derivates | 百时美施贵宝公司 | 2017-08-18 | — | — | CN | disclosed |