SCHEMBL28167359

SCHEMBL28167359

CC(=O)C(c1[c]ccc(-c2ccccc2C)c1)c1ccc(C)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MCL1 Q07820 1/20 0.40
NR1H4 Q96RI1 1/20 0.34
EDNRB P24530 1/20 0.34
EDNRA P25101 1/20 0.34
ALDH1A1 P00352 1/20 0.33
CNR1 P21554 2/20 0.33
CTSA P10619 2/20 0.33
CNR2 P34972 1/20 0.33
FTO Q9C0B1 1/20 0.32
SLC1A3 P43003 1/20 0.32
SLC1A2 P43004 1/20 0.32
SLC1A1 P43005 1/20 0.32
CA12 O43570 1/20 0.32
CA9 Q16790 1/20 0.32
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
S1PR4 O95977 1/20 0.31
AKR1C3 P42330 1/20 0.31
AKR1C2 P52895 1/20 0.31
LMNA P02545 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28167424 0.88 NPC1 (0.33) ALDH1A1CNR1CNR2MEN1KMT2A
SCHEMBL28167440 0.86 AKR1C3 (0.40) EDNRBEDNRACTSAAKR1C3AKR1C2
SCHEMBL9712243 0.73 MCL1 (0.41) MCL1NR1H4EDNRBEDNRACA12
SCHEMBL11641774 0.68 CNR1 (0.54) ALDH1A1CNR1CNR2MEN1KMT2A
SCHEMBL374592 0.66 MCL1 (0.45) MCL1NR1H4EDNRBEDNRAALDH1A1
Acetone SCHEMBL8119850 0.64 STAT3 (0.42) ALDH1A1CNR1CNR2MEN1KMT2A
SCHEMBL10595614 0.64 MCL1 (0.42) MCL1NR1H4CNR1FTOCA12
SCHEMBL8125021 0.64 MCL1 (0.42) MCL1NR1H4EDNRBEDNRACA12
SCHEMBL15638352 0.64 MCL1 (0.42) MCL1NR1H4EDNRBEDNRAALDH1A1
Toluene SCHEMBL27419686 0.63 MEN1 (0.50) ALDH1A1CNR1CNR2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105330522-B Preparation method of benzo [ b ] fluorenone series compounds 江西师范大学 2017-08-08 CN disclosed