Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | PI4KA | P42356 | 1/20 | 0.39 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.39 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL33678 | 0.93 | KDM4E (0.50) | KDM4EPIN1HSD17B10MAPK1USP2 | |
| SCHEMBL28104155 | 0.92 | KDM4E (0.49) | KDM4EPIN1HSD17B10MAPK1USP2 | |
| SCHEMBL28331048 | 0.86 | KDM4E (0.51) | KDM4EPIN1HSD17B10MAPK1USP2 | |
| SCHEMBL22321933 | 0.86 | KDM4E (0.51) | KDM4EPIN1HSD17B10MAPK1USP2 | |
| SCHEMBL8075160 | 0.83 | KDM4E (0.49) | KDM4EPIN1HSD17B10MAPK1USP2 | |
| SCHEMBL16848277 | 0.82 | KDM4E (0.47) | KDM4EPIN1HSD17B10MAPK1USP2 | |
| SCHEMBL16412171 | 0.82 | KDM4E (0.42) | KDM4EPIN1HSD17B10MAPK1USP2 | |
| SCHEMBL29165053 | 0.81 | NISCH (0.46) | KDM4EPIN1HSD17B10MAPK1USP2 | |
| Imidazole SCHEMBL28230383 | 0.80 | KDM4E (0.40) | KDM4EPIN1HSD17B10MAPK1USP2 | |
| SCHEMBL28107791 | 0.80 | TSHR (0.41) | KDM4EPIN1HSD17B10MAPK1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107001582-A | Ester-type epoxy furan resin, method for producing same, resin composition, and resin cured product | 积水化学工业株式会社 | 2017-08-01 | — | — | CN | disclosed |