Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28173505 | 0.86 | SCN9A (0.54) | SCN9ACYP19A1LMNAALDH1A1MAPT | |
| SCHEMBL28173456 | 0.81 | SCN9A (0.55) | SCN9ACYP19A1LMNAALDH1A1MAPT | |
| SCHEMBL17824599 | 0.77 | PARP1 (0.54) | CTSBCYP2C9CYP2C19CYP3A4 | |
| SCHEMBL3894912 | 0.75 | MAOB (0.53) | CTSBLMNATP53ALDH1A1MAPT | |
| SCHEMBL28174293 | 0.74 | SCN9A (0.48) | SCN9ACYP19A1CTSBALDH1A1MAPT | |
| SCHEMBL28385092 | 0.74 | LMNA (0.54) | CTSBLMNATP53ALDH1A1MAPT | |
| SCHEMBL15010833 | 0.73 | SCN9A (0.54) | SCN9AALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL28173419 | 0.73 | SCN9A (0.46) | SCN9ACYP19A1CTSBTP53ALDH1A1 | |
| SCHEMBL28174302 | 0.72 | SCN9A (0.54) | SCN9ATP53ALDH1A1MAPTNPC1 | |
| SCHEMBL28174297 | 0.72 | SCN9A (0.46) | SCN9ACYP19A1CTSBLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107207467-A | 2, 4-dioxo-quinazoline-6-sulfonamide derivatives as inhibitors of PARG | 癌症研究科技有限公司 | 2017-09-26 | — | — | CN | disclosed |