Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 5/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL17963004 | 1.00 | CA4 (0.50) | CA4CA1CA2CA9FAHD1 | |
| Bicarbonate SCHEMBL1263331 | 0.95 | — | — | |
| Bicarbonate SCHEMBL8466588 | 0.95 | CA1 (0.56) | CA4CA1CA2CA9FAHD1 | |
| Bicarbonate SCHEMBL16166367 | 0.95 | CA1 (0.56) | CA4CA1CA2CA9FAHD1 | |
| Bicarbonate SCHEMBL9247678 | 0.95 | CA1 (0.56) | CA4CA1CA2CA9FAHD1 | |
| Bicarbonate SCHEMBL15794084 | 0.90 | CA4 (0.50) | CA4CA1CA2CA9FAHD1 | |
| Bicarbonate SCHEMBL28173546 | 0.90 | CA1 (0.50) | CA4CA1CA2CA9FAHD1 | |
| Bicarbonate SCHEMBL3397287 | 0.90 | CA4 (0.50) | CA4CA1CA2CA9FAHD1 | |
| Bicarbonate SCHEMBL28174366 | 0.90 | CA4 (0.50) | CA4CA1CA2CA9FAHD1 | |
| Bicarbonate SCHEMBL17963008 | 0.90 | CA4 (0.50) | CA4CA1CA2CA9FAHD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107206022-A | Composition containing arsenic and its purposes in treatment method | 益友制药私人有限公司 | 2017-09-26 | — | — | CN | claimed |
| CN-107206022-A | Composition containing arsenic and its purposes in treatment method | 益友制药私人有限公司 | 2017-09-26 | — | — | CN | disclosed |