⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25857099 | 0.90 | HCAR1 (0.31) | — | |
| SCHEMBL24052556 | 0.88 | — | — | |
| SCHEMBL16036398 | 0.84 | TP53 (0.33) | — | |
| SCHEMBL24052553 | 0.84 | — | — | |
| SCHEMBL20913352 | 0.83 | TP53 (0.35) | — | |
| SCHEMBL20959564 | 0.81 | CCNT1 (0.30) | — | |
| SCHEMBL24267967 | 0.81 | — | — | |
| SCHEMBL20913346 | 0.80 | — | — | |
| SCHEMBL4549858 | 0.79 | STK17B (0.38) | — | |
| SCHEMBL29620330 | 0.79 | STK17B (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108434149-A | For the regulated treatments of HSPC of Rb positive abnormal cell proliferations | G1治疗公司 | 2018-08-24 | — | — | CN | disclosed |
| CN-105407889-B | HSPC-sparing therapy for Rb-positive abnormal cell proliferation | G1治疗公司 | 2018-06-01 | — | — | CN | disclosed |
| CN-105473140-B | Transient protection of normal cells during chemotherapy | G1治疗公司 | 2018-04-10 | — | — | CN | disclosed |
| CN-107417691-A | Efficient anti-superfluous raw agent and anti-proliferative agent | G1治疗公司 | 2017-12-01 | — | — | CN | disclosed |