Dapi

Dapi

SCHEMBL28176609

N=C(N)c1ccc(-c2cc3ccc(C(=N)N)cc3[nH]2)cc1.N=C(N)c1ccc(-c2cc3ccc(C(=N)N)cc3[nH]2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PRMT5 O14744 1/20 0.83
PRMT3 O60678 1/20 0.83
CARM1 Q86X55 1/20 0.83
EHMT2 Q96KQ7 1/20 0.83
PRMT6 Q96LA8 1/20 0.83
PRMT1 Q99873 1/20 0.83
WDR77 Q9BQA1 1/20 0.83
PRMT8 Q9NR22 1/20 0.83
PRMT7 Q9NVM4 1/20 0.83
F2 P00734 2/20 0.63
ASIC3 Q9UHC3 1/20 0.56
CASP3 P42574 1/20 0.54
SENP8 Q96LD8 1/20 0.54
SENP7 Q9BQF6 1/20 0.54
SENP6 Q9GZR1 1/20 0.54
F10 P00742 1/20 0.54
PLG P00747 1/20 0.54
PLAU P00749 1/20 0.54
PRSS1 P07477 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dapi SCHEMBL235865 1.00 PRMT5 (0.83) PRMT5PRMT3CARM1EHMT2PRMT6
Dapi SCHEMBL29350295 1.00 PRMT5 (0.83) PRMT5PRMT3CARM1EHMT2PRMT6
Dapi SCHEMBL2464378 0.98 PRMT5 (0.81) PRMT5PRMT3CARM1EHMT2PRMT6
SCHEMBL29428907 0.98 PRMT5 (0.81) PRMT5PRMT3CARM1EHMT2PRMT6
Dapi SCHEMBL94350 0.98 PRMT5 (0.81) PRMT5PRMT3CARM1EHMT2PRMT6
Dapi SCHEMBL30442885 0.98 PRMT5 (0.81) PRMT5PRMT3CARM1EHMT2PRMT6
SCHEMBL14854556 0.98 PRMT5 (0.81) PRMT5PRMT3CARM1EHMT2PRMT6
Dapi SCHEMBL1609032 0.97 PRMT5 (0.79) PRMT5PRMT3CARM1EHMT2PRMT6
Dapi SCHEMBL3492008 0.97 PRMT5 (0.79) PRMT5PRMT3CARM1EHMT2PRMT6
Dapi SCHEMBL15966967 0.97 PRMT5 (0.79) PRMT5PRMT3CARM1EHMT2PRMT6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115807077-B Use of ETS1 in the preparation of a product for diagnosing or treating ciliated disorders 湛江中心人民医院 2023-06-27 CN disclosed
CN-115807077-A Application of ETS1 in preparation of products for diagnosing or treating cilium diseases 湛江中心人民医院 2023-03-17 CN disclosed
CN-104208717-B Double-emulsion core-shell nano structure of conjugated antibody 汇特生物科技股份有限公司 2017-08-25 CN disclosed