Quinoline

Quinoline

SCHEMBL28178121

c1ccc(Cc2ccc3ccccc3n2)cc1.c1ccc2ncccc2c1

nearest known ligand 0.57

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.57
PDE10A Q9Y233 1/20 0.54
CYSLTR1 Q9Y271 4/20 0.50
CYSLTR2 Q9NS75 2/20 0.50
CYP3A4 P08684 2/20 0.49
CYP2D6 P10635 1/20 0.44
SLC6A2 P23975 1/20 0.44
SLC6A4 P31645 1/20 0.44
SLC6A3 Q01959 1/20 0.44
GPBAR1 Q8TDU6 2/20 0.43
CYP1A2 P05177 1/20 0.43
KDM4E B2RXH2 1/20 0.42
NPC1 O15118 1/20 0.42
TP53 P04637 1/20 0.42
HPGD P15428 1/20 0.42
HTT P42858 1/20 0.42
RAB9A P51151 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
HSD17B10 Q99714 1/20 0.42
LMNA P02545 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3253637 0.89 CYSLTR1 (0.55) ALDH1A1CYSLTR1CYSLTR2GPBAR1CYP1A2
Hydrochloric Acid SCHEMBL27514003 0.88 CYSLTR1 (0.53) ALDH1A1CYSLTR1CYSLTR2GPBAR1CYP1A2
SCHEMBL29035750 0.88 CYSLTR1 (0.53) ALDH1A1CYSLTR1CYSLTR2GPBAR1CYP1A2
SCHEMBL22762116 0.86 ALDH1A1 (0.45) ALDH1A1PDE10ACYP3A4
Hydrochloric Acid SCHEMBL28157005 0.86 CYSLTR1 (0.51) ALDH1A1CYSLTR1CYSLTR2GPBAR1CYP1A2
Diphenylmethane SCHEMBL28309004 0.86 ALDH1A1 (0.71) ALDH1A1PDE10ACYP3A4CYP2D6SLC6A2
SCHEMBL21539921 0.85 PDE10A (0.60) ALDH1A1PDE10ACYSLTR1CYSLTR2CYP3A4
Biphenyl SCHEMBL29204423 0.84 CYSLTR1 (0.50) ALDH1A1CYSLTR1CYSLTR2GPBAR1CYP1A2
Biphenyl SCHEMBL29204420 0.83 CYSLTR1 (0.49) ALDH1A1CYSLTR1CYSLTR2GPBAR1CYP1A2
SCHEMBL28236523 0.83 CYSLTR1 (0.49) ALDH1A1CYSLTR1CYSLTR2GPBAR1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107118154-A A kind of molecule-based magnetic compound, crystal and its production and use 南京晓庄学院 2017-09-01 CN claimed