SCHEMBL28186123

SCHEMBL28186123

COc1ccc(-n2ccnc2-c2ccc(Cl)cc2)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GLA P06280 1/20 0.55
MAPKAPK2 P49137 3/20 0.50
MAPT P10636 1/20 0.48
RAB9A P51151 1/20 0.48
RXFP1 Q9HBX9 1/20 0.48
TUBB4A P04350 1/20 0.44
TUBB P07437 1/20 0.44
TUBA3C P0DPH7 1/20 0.44
TUBA1B P68363 1/20 0.44
TUBA4A P68366 1/20 0.44
TUBB4B P68371 1/20 0.44
TUBB3 Q13509 1/20 0.44
TUBB2A Q13885 1/20 0.44
TUBB8 Q3ZCM7 1/20 0.44
TUBA3E Q6PEY2 1/20 0.44
TUBA1A Q71U36 1/20 0.44
TUBA1C Q9BQE3 1/20 0.44
TUBB6 Q9BUF5 1/20 0.44
TUBB2B Q9BVA1 1/20 0.44
TUBB1 Q9H4B7 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29975108 1.00 GLA (0.55) GLAMAPKAPK2MAPTRAB9ARXFP1
SCHEMBL11771718 0.92 KDR (0.49) GLARAB9AKDRPTGS1PTGS2
SCHEMBL5319319 0.87 MAPKAPK2 (0.60) MAPKAPK2PTGS2MAPK9MAPK10
SCHEMBL3278138 0.85 MAPK9 (0.58) MAPKAPK2RAB9AKDRPTGS1PTGS2
SCHEMBL28186197 0.85 KDR (0.55) GLARAB9AKDRCLK4MAPK9
SCHEMBL11385870 0.85 KDR (0.58) GLAMAPTRAB9AKDRCYP1A2
SCHEMBL3270536 0.85 MAPK9 (0.51) MAPKAPK2MAPTRAB9AKDRPTGS1
SCHEMBL28874994 0.85 FLT1 (0.47) GLAMAPTRXFP1TUBB4ATUBB
SCHEMBL28600687 0.85 KMT2A (0.46) GLAMAPTRAB9ATUBB4ATUBB
SCHEMBL27729355 0.84 MAPKAPK2 (0.55) MAPKAPK2KDRPTGS2MAPK9MAPK10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109096139-B Preparation method of alpha-carbonyl amide derivative 贵州大学 2021-03-02 CN disclosed
CN-109096139-A A kind of preparation method of alpha-carbonyl amide derivatives 贵州大学 2018-12-28 CN disclosed
CN-108650887-A Photocurable resin composition, light-shielding coating material, and cured product 日立化成株式会社 2018-10-12 CN disclosed
CN-103019031-B Photosensitive polymer combination and the film and colour filter for having used said composition 东京应化工业株式会社 2017-11-14 CN disclosed