Salicylic Acid

Salicylic Acid

SCHEMBL28186266

CC(Cl)Cl.O=C(O)c1ccccc1O

nearest known ligand 0.75

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Known targets — ChEMBL curated mechanism

ACHE

The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 10/20 0.75
HPGD P15428 8/20 0.75
KDM4E B2RXH2 8/20 0.75
SMN1; SMN2 Q16637 2/20 0.75
CA12 O43570 1/20 0.75
CA1 P00915 1/20 0.75
CA2 P00918 1/20 0.75
HMGB1 P09429 1/20 0.75
CA4 P22748 1/20 0.75
CA6 P23280 1/20 0.75
CA7 P43166 1/20 0.75
CA9 Q16790 1/20 0.75
NAPRT Q6XQN6 1/20 0.75
CA14 Q9ULX7 1/20 0.75
ALOX15 P16050 2/20 0.52
HSD17B10 Q99714 5/20 0.51
LMNA P02545 4/20 0.51
ALOX12 P18054 1/20 0.49
TSHR P16473 2/20 0.48
G6PD P11413 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Salicylic Acid SCHEMBL28185563 0.91 ALDH1A1 (0.82) ALDH1A1HPGDKDM4ESMN1; SMN2CA12
Salicylic Acid SCHEMBL27871001 0.89 ALDH1A1 (0.78) ALDH1A1HPGDKDM4ESMN1; SMN2CA12
Salicylic Acid SCHEMBL15568422 0.89 ALDH1A1 (0.78) ALDH1A1HPGDKDM4ESMN1; SMN2CA12
Salicylic Acid SCHEMBL27880804 0.88 ALDH1A1 (0.75) ALDH1A1HPGDKDM4ESMN1; SMN2CA12
Salicylic Acid SCHEMBL29529431 0.88 ALDH1A1 (0.75) ALDH1A1HPGDKDM4ESMN1; SMN2CA12
Salicylic Acid SCHEMBL5524614 0.88 ALDH1A1 (0.75) ALDH1A1HPGDKDM4ESMN1; SMN2CA12
Salicylic Acid SCHEMBL3280603 0.87 ALDH1A1 (0.90) ALDH1A1HPGDKDM4ESMN1; SMN2CA12
Salicylic Acid SCHEMBL30403392 0.87 ALDH1A1 (0.90) ALDH1A1HPGDKDM4ESMN1; SMN2CA12
Salicylic Acid SCHEMBL29555395 0.87 ALDH1A1 (0.90) ALDH1A1HPGDKDM4ESMN1; SMN2CA12
Salicylic Acid SCHEMBL8029424 0.87 ALDH1A1 (0.90) ALDH1A1HPGDKDM4ESMN1; SMN2CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107434768-B Synthesis method of 5-nitro salicylic acid 中国石油化工股份有限公司 2020-02-21 CN disclosed
CN-107434768-A A kind of synthetic method of 5-NITROSALICYLIC ACID 中国石油化工股份有限公司 2017-12-05 CN disclosed