Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18046173 | 0.87 | HDAC8 (0.45) | ALDH1A1MEN1KMT2AHIF1AMAOB | |
| SCHEMBL18047214 | 0.87 | NR1H4 (0.46) | ALDH1A1MEN1KMT2AHIF1ALMNA | |
| SCHEMBL18047212 | 0.87 | NR1H4 (0.46) | ALDH1A1MEN1KMT2AHIF1ALMNA | |
| SCHEMBL18046176 | 0.87 | HDAC8 (0.45) | ALDH1A1MEN1KMT2AHIF1AMAOB | |
| SCHEMBL28192361 | 0.86 | EPHX1 (0.45) | TRPM8GRIN1GRIN2BEPHX1ALDH1A1 | |
| SCHEMBL18046072 | 0.74 | HDAC8 (0.43) | LMNAMAPTNR3C1OPRM1SLC6A2 | |
| SCHEMBL18046069 | 0.74 | HDAC8 (0.43) | LMNAMAPTNR3C1OPRM1SLC6A2 | |
| SCHEMBL29608620 | 0.74 | HDAC8 (0.43) | LMNAMAPTNR3C1OPRM1SLC6A2 | |
| SCHEMBL6410982 | 0.71 | HDAC6 (0.56) | EPHX1ALDH1A1MEN1KMT2AMAOB | |
| SCHEMBL28191719 | 0.71 | OPRM1 (0.44) | MEN1KMT2ALMNAMAPTNR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107531660-A | α cinnamide compounds and composition as HDAC8 inhibitor | 福马治疗股份有限公司 | 2018-01-02 | — | — | CN | claimed |
| CN-107531660-A | α cinnamide compounds and composition as HDAC8 inhibitor | 福马治疗股份有限公司 | 2018-01-02 | — | — | CN | disclosed |