SCHEMBL28192011

SCHEMBL28192011

NC(=O)N(N)c1cccc(N(N)C(N)=O)c1C(F)(F)F

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 2/20 0.33
CES2 O00748 1/20 0.32
DHODH Q02127 1/20 0.32
KMT2A Q03164 2/20 0.31
MEN1 O00255 1/20 0.31
USP2 O75604 1/20 0.31
KIF11 P52732 2/20 0.31
PARP1 P09874 1/20 0.31
P2RX7 Q99572 1/20 0.31
KCNN4 O15554 1/20 0.31
GAA P10253 1/20 0.31
CCNC P24863 1/20 0.30
CDK8 P49336 1/20 0.30
ALDH1A1 P00352 1/20 0.30
LMNA P02545 1/20 0.30
MAPT P10636 1/20 0.30
PKM P14618 1/20 0.30
HTT P42858 1/20 0.30
KDM4E B2RXH2 1/20 0.30
EPHX1 P07099 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL194877 0.79 LMNA (0.41) KMT2AMEN1KCNN4GAAALDH1A1
SCHEMBL28172033 0.77 TSHR (0.40) KMT2AMEN1PARP1GAAALDH1A1
SCHEMBL27879966 0.75 GAA (0.48) KMT2AMEN1USP2GAAALDH1A1
SCHEMBL28085048 0.74 GAA (0.38) KMT2AMEN1PARP1GAAALDH1A1
SCHEMBL28069281 0.74 PARP1 (0.36) KMT2AMEN1PARP1GAAALDH1A1
SCHEMBL28095001 0.74 KDM4E (0.46) CES2KMT2AMEN1PARP1GAA
SCHEMBL28192976 0.74 MEN1 (0.34) KMT2AMEN1PARP1GAAMAPT
SCHEMBL28042018 0.74 PARP1 (0.36) KMT2AMEN1PARP1GAAMAPT
SCHEMBL28084047 0.73
SCHEMBL28173153 0.72 GAA (0.45) KMT2AMEN1GAAALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107526264-A Annulus, image processing system and annulus unit 富士施乐株式会社 2017-12-29 CN disclosed