Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28854136 | 0.86 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1KDM4EATMMEN1 | |
| SCHEMBL28854139 | 0.79 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1KDM4EATMMEN1 | |
| SCHEMBL18039586 | 0.78 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1KDM4EATMMEN1 | |
| SCHEMBL28854135 | 0.76 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1KDM4EATMMEN1 | |
| SCHEMBL28192204 | 0.76 | SMN1; SMN2 (0.39) | SMN1; SMN2ALDH1A1KDM4EATMMEN1 | |
| SCHEMBL28192182 | 0.76 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1KDM4EATMMEN1 | |
| SCHEMBL18039648 | 0.74 | NPC1 (0.49) | SMN1; SMN2ALDH1A1KDM4EATMMEN1 | |
| SCHEMBL28192167 | 0.74 | SMN1; SMN2 (0.38) | SMN1; SMN2ALDH1A1KDM4EATMMEN1 | |
| SCHEMBL28191537 | 0.73 | SMN1; SMN2 (0.37) | SMN1; SMN2ALDH1A1KDM4EATMMEN1 | |
| SCHEMBL28191551 | 0.70 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1KDM4EATMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107406427-A | Alkynyl alcohols and methods of use thereof | 豪夫迈·罗氏有限公司 | 2017-11-28 | — | — | CN | disclosed |