Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 15/20 | 0.58 |
| ▸ | RAF1 | P04049 | 4/20 | 0.54 |
| ▸ | KDR | P35968 | 3/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.54 |
| ▸ | KIT | P10721 | 2/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.54 |
| ▸ | FLT3 | P36888 | 2/20 | 0.54 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.54 |
| ▸ | BRAF | P15056 | 4/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.50 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL282308 | 0.87 | CSF1R (0.70) | CSF1RRAF1KDRPDGFRBKIT | |
| SCHEMBL282549 | 0.78 | CSF1R (0.72) | CSF1RRAF1KDRPDGFRBKIT | |
| SCHEMBL281954 | 0.76 | CSF1R (0.70) | CSF1RRAF1KDRPDGFRBKIT | |
| SCHEMBL282705 | 0.76 | KDR (0.61) | CSF1RRAF1KDRPDGFRBKIT | |
| SCHEMBL281915 | 0.74 | CDK8 (0.48) | RAF1KDRPDGFRBKITPDGFRA | |
| SCHEMBL10073787 | 0.74 | CSF1R (1.00) | CSF1RRAF1KDRPDGFRBKIT | |
| SCHEMBL22548172 | 0.74 | CSF1R (0.83) | CSF1RAURKB | |
| SCHEMBL717412 | 0.73 | CSF1R (0.77) | CSF1RKDRPDGFRAFLT3AURKB | |
| SCHEMBL22548456 | 0.72 | CSF1R (1.00) | CSF1RKDRPDGFRBKITPDGFRA | |
| SCHEMBL22548194 | 0.70 | CSF1R (0.82) | CSF1RKDRAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428506-A1 | HETEROCYCLIC SUBSTITUTED ACARDITE DERIVATES AND USE THEREOF | Jiangsu Provincial Institute Of Materia Medica Co. (CN) | 2012-03-14 | — | — | EP | claimed |