SCHEMBL28194232

SCHEMBL28194232

CCC(=O)N1CCC(C(=O)N2N=CC[C@H]2c2ccc(F)cc2)CC1

nearest known ligand 0.80

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
RIPK1 Q13546 20/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28194224 1.00 RIPK1 (0.80) RIPK1
SCHEMBL28193738 0.89 RIPK1 (0.72) RIPK1
SCHEMBL28194229 0.89 RIPK1 (0.72) RIPK1
SCHEMBL18248338 0.89 RIPK1 (1.00) RIPK1
SCHEMBL18248367 0.87 RIPK1 (0.78) RIPK1
SCHEMBL18255215 0.87 RIPK1 (0.78) RIPK1
SCHEMBL28854319 0.87 RIPK1 (0.77) RIPK1
SCHEMBL28193737 0.87 RIPK1 (0.77) RIPK1
SCHEMBL28194385 0.86 RIPK1 (0.71) RIPK1
SCHEMBL30175768 0.83 RIPK1 (0.53) RIPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107624111-A Heterocyclic amides as kinase inhibitors 葛兰素史密斯克莱知识产权发展有限公司 2018-01-23 CN disclosed