SCHEMBL28199876

SCHEMBL28199876

NC(=O)c1ccccc1-c1cccc2cccnc12

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 4/20 0.73
ALDH1A1 P00352 3/20 0.51
LMNA P02545 2/20 0.51
ALOX12 P18054 1/20 0.51
CSNK1A1 P48729 1/20 0.49
TYRO3 Q06418 1/20 0.49
DYRK1B Q9Y463 1/20 0.49
GRM5 P41594 1/20 0.48
PLK4 O00444 1/20 0.48
MAP4K4 O95819 1/20 0.48
EGFR P00533 1/20 0.48
ROS1 P08922 1/20 0.48
PIM1 P11309 1/20 0.48
AXL P30530 1/20 0.48
FLT3 P36888 1/20 0.48
FRK P42685 1/20 0.48
MAP4K2 Q12851 1/20 0.48
NTRK3 Q16288 1/20 0.48
MINK1 Q8N4C8 1/20 0.48
AURKB Q96GD4 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29761212 0.87 PARP1 (0.73) PARP1ALDH1A1LMNAALOX12PLK4
SCHEMBL18241111 0.86 PARP1 (0.71) PARP1ALDH1A1LMNAALOX12PLK4
SCHEMBL31032125 0.86 PARP1 (0.71) PARP1ALDH1A1LMNAALOX12PLK4
SCHEMBL27575008 0.85 PARP1 (0.60) PARP1ALDH1A1LMNAALOX12CSNK1A1
SCHEMBL460456 0.84 PARP1 (1.00) PARP1ALDH1A1LMNAALOX12PLK4
SCHEMBL29923346 0.84 PARP1 (1.00) PARP1ALDH1A1LMNAALOX12PLK4
SCHEMBL29959688 0.84 PARP1 (1.00) PARP1ALDH1A1LMNAALOX12PLK4
SCHEMBL29563583 0.84 PARP1 (0.59) PARP1ALDH1A1LMNAALOX12PLK4
SCHEMBL28870717 0.84 PARP1 (0.59) PARP1ALDH1A1LMNAGRM5PLK4
Hydrochloric Acid SCHEMBL29933479 0.83 PARP1 (0.96) PARP1ALDH1A1LMNAALOX12PLK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4514949-A1 METHODS AND COMPOSITIONS FOR TREATING VISION LOSS Hadasit Medical Research Services&Development Ltd. (IL) 2025-03-05 EP claimed
WO-2023211857-A1 METHODS AND COMPOSITIONS FOR TREATING VISION LOSS Lineage Cell Therapeutics, Inc. (US) 2023-11-02 WO claimed
EP-4581017-A1 NEW N-HETEROARYLBENZAMIDES DERIVATIVES AS FLT3 INHIBITORS Biodol Therapeutics (FR) 2025-07-09 EP disclosed
EP-4514949-A1 METHODS AND COMPOSITIONS FOR TREATING VISION LOSS Hadasit Medical Research Services&Development Ltd. (IL) 2025-03-05 EP disclosed
WO-2024079072-A1 NEW N-HETEROARYLBENZAMIDES DERIVATIVES AS FLT3 INHIBITORS BIODOL THERAPEUTICS (FR) 2024-04-18 WO disclosed
CN-117486795-A Preparation method of deuterated amide aromatic compound 浙大宁波理工学院 2024-02-02 CN disclosed
WO-2023211857-A1 METHODS AND COMPOSITIONS FOR TREATING VISION LOSS Lineage Cell Therapeutics, Inc. (US) 2023-11-02 WO disclosed
EP-4037685-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE Neurodon Corporation (US) 2022-08-10 EP disclosed
CN-110022875-A Therapeutic inhibiting compound 莱福斯希医药公司 2019-07-16 CN disclosed
CN-107698586-A It is a kind of that the method for preparing Pyridine-quinazolinocompound compound is catalyzed by copper compound 广州大学 2018-02-16 CN disclosed