SCHEMBL460456

SCHEMBL460456

NC(=O)c1cccc2cccnc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 11/20 1.00
PLK4 O00444 1/20 0.57
MAP4K4 O95819 1/20 0.57
EGFR P00533 1/20 0.57
ROS1 P08922 1/20 0.57
PIM1 P11309 1/20 0.57
AXL P30530 1/20 0.57
FLT3 P36888 1/20 0.57
FRK P42685 1/20 0.57
MAP4K2 Q12851 1/20 0.57
NTRK3 Q16288 1/20 0.57
MINK1 Q8N4C8 1/20 0.57
AURKB Q96GD4 1/20 0.57
HIPK2 Q9H2X6 1/20 0.57
MKNK2 Q9HBH9 1/20 0.57
IRAK4 Q9NWZ3 1/20 0.57
STK17A Q9UEE5 1/20 0.57
ALK Q9UM73 1/20 0.57
ALDH1A1 P00352 3/20 0.57
LMNA P02545 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29923346 1.00 PARP1 (1.00) PARP1PLK4MAP4K4EGFRROS1
SCHEMBL29959688 1.00 PARP1 (1.00) PARP1PLK4MAP4K4EGFRROS1
Hydrochloric Acid SCHEMBL29933479 0.98 PARP1 (0.96) PARP1PLK4MAP4K4EGFRROS1
Hydrochloric Acid SCHEMBL18094592 0.98 PARP1 (0.96) PARP1PLK4MAP4K4EGFRROS1
SCHEMBL29256793 0.93 PARP1 (0.87) PARP1PLK4MAP4K4EGFRROS1
Fumaric Acid SCHEMBL18094591 0.90 PARP1 (0.81) PARP1PLK4MAP4K4EGFRROS1
Fumaric Acid SCHEMBL18094590 0.90 PARP1 (0.81) PARP1PLK4MAP4K4EGFRROS1
Quinoline SCHEMBL28083721 0.90 PARP1 (0.81) PARP1PLK4MAP4K4EGFRROS1
SCHEMBL29761212 0.84 PARP1 (0.73) PARP1PLK4MAP4K4EGFRROS1
SCHEMBL28199876 0.84 PARP1 (0.73) PARP1PLK4MAP4K4EGFRROS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 230 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4251624-B1 TRICYCLIC CARBOXAMIDE DERIVATIVES AS PRMT5 INHIBITORS AMGEN INC (US) 2025-10-29 EP claimed
CN-117836306-A Galactose glycoside derivatives as galectin-3 inhibitors 株式会社蒂奥姆生物 2024-04-05 CN claimed
EP-4288435-A1 TRICYCLIC-AMIDO-BICYCLIC PRMT5 INHIBITORS Amgen Inc. (US) 2023-12-13 EP claimed
EP-4251624-A1 TRICYCLIC CARBOXAMIDE DERIVATIVES AS PRMT5 INHIBITORS Amgen, Inc (US) 2023-10-04 EP claimed
WO-2022115377-A1 TRICYCLIC CARBOXAMIDE DERIVATIVES AS PRMT5 INHIBITORS AMGEN INC. (US) 2022-06-02 WO claimed
CN-111320579-B Preparation method of 8-amide-5-halogenated quinoline derivative 常州工程职业技术学院 2021-06-29 CN claimed
CN-111320579-A Preparation method of 8-amide-5-halogenated quinoline derivative 常州工程职业技术学院 2020-06-23 CN claimed
CN-106414432-B Optionally substituted quinoline compounds 卫材R&D管理有限公司 2019-06-14 CN claimed
CN-105492444-B Tricyclic pyridine-carboxamide derivatives as ROCK inhibitors 百时美施贵宝公司 2018-09-07 CN claimed
CN-108430992-A QUINOLINE-3-CARBOXAMIDES AS H-PGDS INHIBITORS 阿斯特克斯医疗公司 2018-08-21 CN claimed
EP-1299395-B1 OXAZINOQUINOLONES USEFUL FOR THE TREATMENT OF VIRAL INFECTIONS UPJOHN CO (US) 2004-09-15 EP claimed
WO-2004072046-A2 QUINOLINE DERIVATIVES AND THEIR USE FOR MODULATION OF LXR ACTIVITY CAREX S.A. (FR) 2004-08-26 WO claimed
CN-1507434-A Novel 4-anilinoquinoline-3-carboxamides 2004-06-23 CN claimed
WO-2004019932-A1 METHOD OF PREVENTING OR TREATING ATHEROSCLEROSIS OR RESTENOSIS PHARMACIA & UPJOHN COMPANY (US) 2004-03-11 WO claimed
CN-1128790-C 4-hydroxyquinoline-3-carboxamides and hydrazides as antiviral agents UPJOHN CO (US) 2003-11-26 CN claimed
EP-0839145-B1 HETEROCYCLYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS ABBOTT GMBH & CO KG (DE) 2003-11-05 EP claimed
CN-1092642-C Use as tachykinin NK3Quinoline derivatives of receptor antagonists SMITHKLINE BEECHAM FARMA (IT) 2002-10-16 CN claimed
CN-1281439-A 4-hydroxyquinoline-3-carboxamide and hydrazide compounds as antiviral agents UPJOHN CO (US) 2001-01-24 CN claimed
US-6093732-A PREVENT HERPESVIRAL INFECTIONS, PARTICULARLY, HUMAN CYTOMEGALOVIRAL INFECTION PHARMACIA & UPJOHN COMPANY (US) 2000-07-25 US claimed
CN-1156451-A Use as tachykinin NK3Quinoline derivatives of receptor antagonists SMITHKLINE BEECHAM FARMA (IT) 1997-08-06 CN claimed