Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 11/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CTSC | P53634 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2827759 | 0.99 | TRPM8 (0.54) | TRPM8SMN1; SMN2L3MBTL1MAPTLMNA | |
| SCHEMBL2820211 | 0.91 | TRPM8 (0.56) | TRPM8SMN1; SMN2L3MBTL1MAPTLMNA | |
| Hydrochloric Acid SCHEMBL2821111 | 0.90 | TRPM8 (0.55) | TRPM8SMN1; SMN2L3MBTL1MAPTLMNA | |
| SCHEMBL2819239 | 0.89 | CTSC (0.54) | TRPM8SMN1; SMN2L3MBTL1MAPTLMNA | |
| Hydrochloric Acid SCHEMBL2827762 | 0.89 | CTSC (0.53) | TRPM8SMN1; SMN2L3MBTL1MAPTLMNA | |
| SCHEMBL2824172 | 0.80 | TRPM8 (0.51) | TRPM8SMN1; SMN2L3MBTL1MAPTLMNA | |
| SCHEMBL2822086 | 0.80 | TRPM8 (0.62) | TRPM8SMN1; SMN2L3MBTL1MAPTLMNA | |
| SCHEMBL2820941 | 0.80 | TRPM8 (0.68) | TRPM8SMN1; SMN2L3MBTL1MAPTLMNA | |
| Hydrochloric Acid SCHEMBL2824138 | 0.80 | TRPM8 (0.50) | TRPM8SMN1; SMN2L3MBTL1MAPTLMNA | |
| SCHEMBL2821539 | 0.78 | TRPM8 (0.60) | TRPM8SMN1; SMN2L3MBTL1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742634-B1 | POLYCYCLIC PYRIMIDINES AS POTASSIUM ION CHANNEL MODULATORS | ICAGEN INC (US) | 2010-10-27 | — | — | EP | claimed |
| US-7560464-B2 | Polycyclic pyrimidines as potassium ion channel modulators | ICAGEN, INC. (US) | 2009-07-14 | — | — | US | claimed |
| EP-1742634-B1 | POLYCYCLIC PYRIMIDINES AS POTASSIUM ION CHANNEL MODULATORS | ICAGEN INC (US) | 2010-10-27 | — | — | EP | disclosed |