SCHEMBL28200136

SCHEMBL28200136

N#Cc1ccc(NN)c(C#N)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.43
KDM4E B2RXH2 2/20 0.43
GAA P10253 2/20 0.43
LRRK2 Q5S007 2/20 0.39
LMNA P02545 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
STS P08842 1/20 0.37
IMPDH2 P12268 1/20 0.37
IMPDH1 P20839 1/20 0.37
IDO1 P14902 2/20 0.35
CXCR2 P25025 3/20 0.35
CXCR1 P25024 2/20 0.35
KAT2B Q92831 1/20 0.35
LOXL2 Q9Y4K0 1/20 0.34
CA2 P00918 2/20 0.33
CYP2A6 P11509 2/20 0.33
CA1 P00915 1/20 0.33
CA12 O43570 1/20 0.33
CA3 P07451 1/20 0.33
CA6 P23280 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL20984367 0.98 KDM4E (0.42) ALDH1A1KDM4EGAALRRK2LMNA
Hydrochloric Acid SCHEMBL20984507 0.98 KDM4E (0.42) ALDH1A1KDM4EGAALRRK2LMNA
Bromide SCHEMBL20984917 0.91 KDM4E (0.38) ALDH1A1KDM4EGAALRRK2LMNA
Sulfuric Acid SCHEMBL20984209 0.89 STS (0.41) ALDH1A1KDM4EGAALRRK2STS
Oxalic Acid SCHEMBL20984938 0.89 CXCR2 (0.42) ALDH1A1KDM4EGAASTSCXCR2
Oxalic Acid SCHEMBL20984936 0.89 CXCR2 (0.42) ALDH1A1KDM4EGAASTSCXCR2
Phosphoric Acid SCHEMBL20984966 0.89 MMP2 (0.40) ALDH1A1KDM4EGAALRRK2STS
Nitric Acid SCHEMBL20984350 0.87 KAT2B (0.43) ALDH1A1KDM4EGAALMNACXCR2
SCHEMBL28200176 0.83 KDM4E (0.40) ALDH1A1KDM4EGAALMNAL3MBTL1
Bromide SCHEMBL20984939 0.82 KDM4E (0.39) ALDH1A1KDM4EGAALMNAL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107663161-A A kind of continuous stream synthesis technique of phenylhydrazine salt and substituted benzene hydrazonium salt 上海惠和化德生物科技有限公司 2018-02-06 CN disclosed