Dioxane

Dioxane

SCHEMBL28200327

C1COCCO1.O=C(O)CNc1ccccc1

nearest known ligand 0.49

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.49
KDM4E B2RXH2 2/20 0.47
HTT P42858 1/20 0.47
LMNA P02545 4/20 0.46
SMN1; SMN2 Q16637 3/20 0.46
CYP2C19 P33261 2/20 0.46
CYP2C9 P11712 1/20 0.46
GAA P10253 3/20 0.45
ABAT P80404 1/20 0.44
ERCC1 P07992 1/20 0.42
ERCC4 Q92889 1/20 0.42
DPP7 Q9UHL4 1/20 0.42
FFAR1 O14842 1/20 0.42
MAPT P10636 4/20 0.41
NPSR1 Q6W5P4 2/20 0.41
HPGD P15428 1/20 0.41
PKM P14618 1/20 0.41
AKR1C3 P42330 1/20 0.41
KMT2A Q03164 2/20 0.41
MEN1 O00255 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fluoride SCHEMBL7426005 0.90 ABAT (0.52) ALDH1A1KDM4ELMNASMN1; SMN2GAA
SCHEMBL1330698 0.88 ABAT (0.53) ALDH1A1KDM4ELMNASMN1; SMN2GAA
Hydrochloric Acid SCHEMBL2006870 0.88 ABAT (0.53) ALDH1A1KDM4ELMNASMN1; SMN2GAA
Benzene SCHEMBL27714747 0.88 ABAT (0.53) ALDH1A1KDM4ELMNASMN1; SMN2GAA
SCHEMBL41828 0.88 ABAT (0.53) ALDH1A1KDM4ELMNASMN1; SMN2GAA
Hydrochloric Acid SCHEMBL3069393 0.88 ABAT (0.53) ALDH1A1KDM4ELMNASMN1; SMN2GAA
SCHEMBL7785939 0.88 ABAT (0.53) ALDH1A1KDM4ELMNASMN1; SMN2GAA
SCHEMBL4091646 0.86 ABAT (0.52) ALDH1A1KDM4ELMNASMN1; SMN2GAA
Methane SCHEMBL5247717 0.86 ABAT (0.52) ALDH1A1KDM4ELMNASMN1; SMN2GAA
SCHEMBL2573295 0.86 ABAT (0.52) ALDH1A1KDM4ELMNASMN1; SMN2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105418516-B A kind of quinazoline compounds and preparation method thereof 信阳师范学院 2018-03-02 CN disclosed