Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | PTPRF | P10586 | 1/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28953078 | 0.95 | RAB9A (0.54) | RAB9AATMPOLBPTPRFPTPN2 | |
| SCHEMBL5788955 | 0.83 | ELANE (0.58) | ATMPOLBKMT2AMEN1ELANE | |
| SCHEMBL775369 | 0.81 | TDP1 (0.48) | RAB9APOLBKMT2AMEN1ELANE | |
| SCHEMBL5401016 | 0.81 | ELANE (0.55) | ATMPOLBKMT2AMEN1ELANE | |
| SCHEMBL11898542 | 0.80 | MIF (0.43) | RAB9AATMPOLBKMT2AMEN1 | |
| SCHEMBL11898583 | 0.78 | MIF (0.43) | RAB9AATMPOLBKMT2AMEN1 | |
| SCHEMBL28823439 | 0.78 | ELANE (0.47) | RAB9APOLBKMT2AELANESMN1; SMN2 | |
| SCHEMBL14335438 | 0.77 | SRD5A2 (0.62) | RAB9AATMPOLBKMT2AMEN1 | |
| SCHEMBL6654105 | 0.77 | TSHR (0.48) | POLBELANESMN1; SMN2LMNATDP1 | |
| SCHEMBL26622715 | 0.77 | SRD5A2 (0.62) | RAB9AATMPOLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107646036-A | Pyrazole derivatives useful as inhibitors of 5-lipoxygenase activating protein (F L AP) | 阿斯利康(瑞典)有限公司 | 2018-01-30 | — | — | CN | disclosed |