Known targets — ChEMBL curated mechanism
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The experimentally established mechanism targets of Di(Hydroxyethyl)Ether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Di(Hydroxyethyl)Ether SCHEMBL1616901 | 0.92 | TSHR (0.62) | TSHRMAPK1ALDH1A1MEN1KMT2A | |
| Di(Hydroxyethyl)Ether SCHEMBL27602303 | 0.92 | TSHR (0.62) | TSHRMAPK1ALDH1A1MEN1KMT2A | |
| Di(Hydroxyethyl)Ether SCHEMBL28517387 | 0.90 | ALDH1A1 (0.59) | TSHRMAPK1ALDH1A1MEN1KMT2A | |
| Di(Hydroxyethyl)Ether SCHEMBL27903400 | 0.90 | TSHR (0.53) | TSHRMAPK1ALDH1A1MEN1KMT2A | |
| Di(Hydroxyethyl)Ether SCHEMBL6658442 | 0.89 | TSHR (0.59) | TSHRMAPK1ALDH1A1MEN1KMT2A | |
| Triethylene Glycol SCHEMBL21081708 | 0.89 | MEN1 (0.65) | TSHRMAPK1ALDH1A1MEN1KMT2A | |
| Triethylene Glycol SCHEMBL618788 | 0.89 | MEN1 (0.65) | TSHRMAPK1ALDH1A1MEN1KMT2A | |
| Tetraethylene Glycol SCHEMBL617711 | 0.89 | MEN1 (0.65) | TSHRMAPK1ALDH1A1MEN1KMT2A | |
| Pentaethylene Glycol SCHEMBL6681000 | 0.89 | MEN1 (0.65) | TSHRMAPK1ALDH1A1MEN1KMT2A | |
| Hexaethylene Glycol SCHEMBL11352521 | 0.89 | MEN1 (0.65) | TSHRMAPK1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107735488-A | Low solvent liquid detergent composition | 宝洁公司 | 2018-02-23 | — | — | CN | disclosed |