Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phaseolin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.90 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | TTR | P02766 | 1/20 | 0.51 |
| ▸ | TYR | P14679 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phaseolin SCHEMBL28209786 | 0.99 | MGAM (0.89) | MGAMPTPN1CYP3A4HSP90AA1NPC1 | |
| Phaseolin SCHEMBL29351585 | 0.95 | MGAM (1.00) | MGAMPTPN1CYP3A4HSP90AA1NPC1 | |
| Phaseolin SCHEMBL33735 | 0.95 | MGAM (1.00) | MGAMPTPN1CYP3A4HSP90AA1NPC1 | |
| Phaseolin SCHEMBL29929606 | 0.95 | MGAM (1.00) | MGAMPTPN1CYP3A4HSP90AA1NPC1 | |
| Phaseolin SCHEMBL33736 | 0.95 | MGAM (1.00) | MGAMPTPN1CYP3A4HSP90AA1NPC1 | |
| Phaseolin SCHEMBL28856370 | 0.94 | MGAM (0.98) | MGAMPTPN1CYP3A4HSP90AA1NPC1 | |
| Phaseolin SCHEMBL8966811 | 0.84 | MGAM (0.75) | MGAMPTPN1CYP3A4HSP90AA1NPC1 | |
| Shinpterocarpin SCHEMBL29377666 | 0.83 | MGAM (0.77) | MGAMPTPN1CYP3A4HSP90AA1NPC1 | |
| Shinpterocarpin SCHEMBL30001940 | 0.83 | MGAM (0.77) | MGAMPTPN1CYP3A4HSP90AA1NPC1 | |
| Phaseolin SCHEMBL7858491 | 0.82 | MGAM (0.72) | MGAMPTPN1CYP3A4HSP90AA1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107875187-A | A kind of medicinal composition for injections of phaseolin | 成都源来来科技有限公司 | 2018-04-06 | — | — | CN | claimed |
| CN-107875187-A | A kind of medicinal composition for injections of phaseolin | 成都源来来科技有限公司 | 2018-04-06 | — | — | CN | disclosed |
| CN-107737152-A | A kind of preparation method of phaseolin injection agent medicine composition | 成都源来来科技有限公司 | 2018-02-27 | — | — | CN | disclosed |