Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 6/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.56 |
| ▸ | CDK2 | P24941 | 5/20 | 0.56 |
| ▸ | CLK1 | P49759 | 4/20 | 0.56 |
| ▸ | CLK2 | P49760 | 5/20 | 0.53 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.53 |
| ▸ | CDK1 | P06493 | 2/20 | 0.51 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.51 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.51 |
| ▸ | CDK4 | P11802 | 1/20 | 0.50 |
| ▸ | SYK | P43405 | 4/20 | 0.46 |
| ▸ | SMO | Q99835 | 1/20 | 0.46 |
| ▸ | CLK3 | P49761 | 2/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28856408 | 0.84 | DYRK1A (0.64) | DYRK1ACLK4CDK2CLK1CLK2 | |
| SCHEMBL28201500 | 0.81 | CLK4 (0.58) | DYRK1ACLK4CDK2CLK1CLK2 | |
| SCHEMBL28200962 | 0.80 | DYRK1A (0.53) | DYRK1ACLK4CDK2CLK1CLK2 | |
| SCHEMBL27114006 | 0.78 | CCNB2 (0.52) | CDK2CDK1RETCCNB2CCNB1 | |
| SCHEMBL29481867 | 0.78 | DYRK1A (0.62) | DYRK1ACLK4CDK2CLK1CLK2 | |
| SCHEMBL28727089 | 0.78 | DYRK1A (0.62) | DYRK1ACLK4CDK2CLK1CLK2 | |
| SCHEMBL14519531 | 0.77 | CDK4 (0.57) | CDK2CDK1RETCCNB2CCNB1 | |
| SCHEMBL27116075 | 0.77 | CCNB2 (0.55) | CDK2CDK1RETCCNB2CCNB1 | |
| SCHEMBL28201525 | 0.76 | ABL1 (0.63) | DYRK1ACLK4CDK2CLK1CLK2 | |
| SCHEMBL3760002 | 0.76 | SYK (0.60) | DYRK1ACLK4CDK2CLK1CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107721991-B | A kind of 6- (pyrimidine-4-yl) -1H- indazole derivative and its preparation method and application | 南方医科大学中西医结合医院 | 2019-10-18 | — | — | CN | disclosed |
| CN-107721991-A | A kind of 6 (base of pyrimidine 4) 1H indazole derivatives and its preparation method and application | 南方医科大学中西医结合医院 | 2018-02-23 | — | — | CN | disclosed |