Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.63 |
| ▸ | BCR | P11274 | 1/20 | 0.63 |
| ▸ | PRKCA | P17252 | 1/20 | 0.63 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.63 |
| ▸ | CAMK2D | Q13557 | 6/20 | 0.61 |
| ▸ | CDK2 | P24941 | 5/20 | 0.58 |
| ▸ | CLK1 | P49759 | 2/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.58 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.58 |
| ▸ | CLK2 | P49760 | 1/20 | 0.57 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.57 |
| ▸ | PLK1 | P53350 | 1/20 | 0.57 |
| ▸ | SYK | P43405 | 1/20 | 0.55 |
| ▸ | BTK | Q06187 | 1/20 | 0.55 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.54 |
| ▸ | CDK4 | P11802 | 2/20 | 0.53 |
| ▸ | CDK1 | P06493 | 2/20 | 0.53 |
| ▸ | SMG1 | Q96Q15 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28201500 | 0.87 | CLK4 (0.58) | ABL1BCRPRKCAPRKCDCAMK2D | |
| SCHEMBL27115512 | 0.84 | CLK1 (0.61) | CDK2CLK1DYRK1ACLK4CLK2 | |
| SCHEMBL28856408 | 0.83 | DYRK1A (0.64) | ABL1PRKCDCAMK2DCDK2CLK1 | |
| SCHEMBL27115203 | 0.81 | ABL1 (0.61) | ABL1BCRPRKCAPRKCDCAMK2D | |
| SCHEMBL3246795 | 0.81 | NUDT1 (0.62) | ABL1BCRPRKCAPRKCDCAMK2D | |
| SCHEMBL3760002 | 0.80 | SYK (0.60) | ABL1PRKCAPRKCDCAMK2DCDK2 | |
| SCHEMBL3510842 | 0.79 | ABL1 (0.75) | ABL1BCRPRKCAPRKCDCAMK2D | |
| SCHEMBL27114009 | 0.79 | CAMK2D (0.63) | ABL1BCRPRKCAPRKCDCAMK2D | |
| SCHEMBL3513778 | 0.78 | CAMK2D (0.73) | ABL1BCRPRKCAPRKCDCAMK2D | |
| SCHEMBL30847308 | 0.78 | SMO (0.60) | CAMK2DCDK2CLK1DYRK1ACLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107721991-B | A kind of 6- (pyrimidine-4-yl) -1H- indazole derivative and its preparation method and application | 南方医科大学中西医结合医院 | 2019-10-18 | — | — | CN | disclosed |
| CN-107721991-A | A kind of 6 (base of pyrimidine 4) 1H indazole derivatives and its preparation method and application | 南方医科大学中西医结合医院 | 2018-02-23 | — | — | CN | disclosed |